perturbation	description	hypothesis
MG-132	MG‑132 is a laboratory compound that blocks the cell’s protein‑degradation machinery, the proteasome.	It might mimic exercise in gastrocnemius by possibly increasing the stability of proteins that promote muscle remodeling and metabolic signaling.
simvastatin	Simvastatin is a cholesterol‑lowering medication that may also provoke some of the same metabolic shifts in the liver that occur during physical activity.	It might mimic exercise by possibly activating AMPK signaling and boosting fatty‑acid oxidation in liver cells.
LATS2	LATS2 is a gene that helps regulate cell growth, and altering its activity can change how testicular cells behave; when its function is reduced, the cells may lose characteristics associated with an exercise‑like state.	It might push cells away from an exercise‑like state possibly by weakening Hippo pathway signaling, which reduces the expression of genes linked to metabolic fitness.
VX-765	VX‑765 is an experimental drug that blocks a key inflammatory enzyme, helping to reduce tissue inflammation.	It may mimic exercise in heart tissue by possibly dampening inflammasome‑driven inflammation and thereby promoting healthier cardiac signaling.
TLR8	TLR8 is a receptor that senses viral RNA, triggering immune responses in the spleen.	It might mimic exercise by possibly stimulating inflammatory signaling that enhances immune cell turnover and metabolic remodeling in splenic tissue.
CASP8	Caspase‑8 (CASP8) is an enzyme that helps trigger programmed cell death and is active in many tissues, including the testes.	Possibly, heightened CASP8 activity could increase apoptosis of germ cells, diminishing the metabolic and signaling changes that normally resemble an exercise‑like state.
PLA2G2D	PLA2G2D is an enzyme that helps break down specific fats and plays a role in regulating inflammation.	It might mimic aspects of exercise in testes possibly by altering local lipid signaling that influences hormone production and cellular stress responses.
ifosfamide	Ifosfamide is a chemotherapy drug that interferes with DNA replication in fast‑growing cells and is used to treat various cancers.	It might mimic exercise effects in ovarian tissue possibly by generating modest oxidative stress that activates shared metabolic and signaling pathways involved in cellular adaptation.
SA-1447005	SA-1447005 is a compound that seems to move adrenal cells away from the gene‑activity pattern typical of an exercised state.	Possibly it disrupts the signaling cascade that normally triggers exercise‑related transcription factors in adrenal cells.
barasertib-HQPA	Barasertib‑HQPA is an experimental compound that blocks Aurora‑B kinase, a protein that regulates cell division and is being investigated for cancer therapy.	It might mimic exercise effects in the hippocampus possibly by modulating DNA‑damage response and stress‑signaling pathways that intersect with neuroplasticity mechanisms activated by physical activity.
azacitidine	Azacitidine is a drug that interferes with the way cells copy their DNA, and it’s used in some cancer treatments.	It might push liver cells away from an exercise‑like state possibly by demethylating genes that regulate metabolic pathways, thereby altering their activity.
C1ORF56	C1ORF56 is a little‑studied gene that encodes a protein of unknown function, expressed in blood cells and detected in RNA‑sequencing studies.	It may push cells away from an exercise‑like state possibly by modulating inflammatory signaling pathways that oppose the metabolic reprogramming normally triggered by physical activity.
ivabradine	Ivabradine is a drug that slows the heart’s pacemaker activity, lowering heart rate and reducing the heart’s workload.	It might mimic exercise in testes by possibly lowering cardiac output, which could trigger systemic metabolic signals (e.g., AMPK activation) that enhance mitochondrial activity and stress‑response pathways in testicular cells.
ORAI1	ORAI1 is a protein that creates calcium channels in muscle cells, helping regulate the flow of calcium that controls many cellular functions.	It might mimic exercise effects in vastus lateralis by modifying calcium signaling pathways that activate muscle growth and metabolic adaptations.
TG-101348	TG‑101348 is a small‑molecule compound that appears to dampen the activity of brown‑fat cells, making them behave less like they do during exercise.	It might push cells away from an exercise‑like state possibly by inhibiting JAK2/STAT3 signaling, which reduces thermogenic gene expression.
resminostat	Resminostat is an experimental drug that inhibits histone deacetylase enzymes, which regulate gene activity, and is being investigated primarily for anti‑cancer properties.	It may push brown‑adipose cells away from an exercise‑like state possibly by lowering the expression of thermogenic genes that rely on histone deacetylase–mediated chromatin remodeling.
NNT	NNT (nicotinamide nucleotide transhydrogenase) is a protein that helps cells balance energy and protect against oxidative stress, and altering its activity in kidney cells produces changes that resemble those seen after exercise.	It might mimic exercise by increasing mitochondrial NADPH production, which could boost antioxidant defenses and metabolic flexibility in kidney tissue.
AZ-628	AZ-628 is a small‑molecule inhibitor that blocks RAF kinases, which are key regulators of cell growth and signaling.	It may mimic exercise in the small intestine possibly by suppressing MAPK signaling and thereby inducing compensatory metabolic and proliferative pathways that resemble those triggered by physical activity.
etofylline-clofibrate	Etofylline-clofibrate is a drug combination that mixes a heart‑stimulating compound with a cholesterol‑lowering agent, sometimes used to treat metabolic disorders.	It may push testicular cells away from an exercise‑like state possibly by disrupting mitochondrial energy production and altering fatty‑acid signaling pathways.
PRSS8	PRSS8 (prostasin) is a membrane‑bound serine protease that helps regulate ion transport and signaling in many tissues, including the adrenal gland.	It may push adrenal cells away from an exercise‑like state possibly by altering sodium‑channel activity and downstream metabolic signaling pathways.
LGX-818	LGX‑818 is an experimental drug that blocks a specific protein inside kidney cells, and early tests suggest it may prevent the cells from adopting the beneficial, “exercise‑like” changes seen after physical activity.	It might push cells away from an exercise‑like state by inhibiting a signaling pathway (such as MAPK/ERK) that normally promotes metabolic adaptations associated with exercise.
clonazepam	Clonazepam is a prescription drug often used to treat anxiety and seizure disorders, and our screening suggests it may mimic some molecular effects of exercise in blood RNA.	It might mimic exercise‑related changes possibly by modulating GABA‑ergic signaling, which can influence metabolic and inflammatory pathways also activated during physical activity.
seocalcitol	Seocalcitol is a synthetic vitamin D analog that can affect cell signaling and growth, and is being studied for its potential effects on brain cells.	It might push cortical cells away from an exercise‑like state by altering calcium‑dependent signaling pathways that regulate neuronal activity.
BTN1A1	BTN1A1 encodes a protein that helps move sugar molecules across cell membranes, and changes in its activity can affect how blood cells function.	It could push cells away from an exercise-like state possibly by altering glucose transport and downstream energy‑sensing pathways that normally respond to physical activity.
PSMB2	PSMB2 is a protein that helps break down other proteins inside cells, and turning it on in fat tissue seems to make the tissue act a bit like it does after a workout.	It might mimic exercise by enhancing proteasomal turnover, which could boost mitochondrial function and promote the browning of white fat.
vandetanib	Vandetanib is a cancer drug that blocks specific growth‑factor receptors, originally approved for treating certain thyroid cancers.	It might push gastrocnemius cells away from an exercise‑like state possibly by inhibiting VEGFR and EGFR signaling, which could dampen the metabolic and angiogenic pathways normally activated during exercise.
SIRT6	SIRT6 is a protein that helps control DNA repair and metabolism in brain cells, and altering its activity can change how these cells respond to exercise‑like signals.	It might push cells away from an exercise‑like state possibly by reshaping metabolic pathways and dampening the activation of exercise‑responsive genes.
2-(4-Chlorophenyl)-5-(prop-2-enylamino)-4-oxazolecarbonitrile	2-(4-Chlorophenyl)-5-(prop-2-enylamino)-4-oxazolecarbonitrile is a synthetic organic compound featuring a chlorine‑substituted phenyl ring, an oxazole heterocycle, and a nitrile group.	It may mimic exercise effects in gastrocnemius tissue possibly by activating AMPK signaling and promoting mitochondrial biogenesis.
IPPK	IPPK is a small protein that appears to reduce the activity of adrenal cells that normally respond to exercise‑like signals.	It might push cells away from an exercise‑like state possibly by dampening signaling pathways that stimulate hormone production during physical activity.
GPR25	GPR25 is a brain‑expressed receptor that, when altered, appears to influence memory and mood in ways similar to the benefits of regular exercise.	It may mimic exercise effects by modulating neurotrophic signaling pathways that are also activated during physical activity.
1H-Benzimidazole-2-acetonitrile, alpha-((5-nitro-2-furanyl)methylene)-	1H‑Benzimidazole‑2‑acetonitrile, alpha‑((5‑nitro‑2‑furanyl)methylene) is a small synthetic molecule that combines a benzimidazole ring with a nitro‑furanyl side chain.	It might push kidney cells away from an exercise‑like state by possibly disrupting nitric‑oxide signaling or mitochondrial energy production.
LY-303511	LY-303511 is a small‑molecule compound that seems to dampen the exercise‑like activity of cells in the small intestine.	It may push cells away from an exercise‑like state by inhibiting a signaling pathway that normally drives mitochondrial biogenesis, such as AMPK/PGC‑1α activation.
TRRAP	TRRAP is a protein that helps regulate gene expression, and changing its activity can disturb normal cellular behavior.	It might push cells away from an exercise‑like state possibly by impairing the activation of metabolic pathways that are normally up‑regulated during physical activity.
EDNRB	EDNRB encodes the endothelin‑B receptor, a protein on lung cells that helps control blood‑vessel tone and signaling.	Possibly by dampening endothelin‑B signaling, it may reduce nitric‑oxide production and vascular remodeling that are typical of an exercise‑like state.
CCNA2	Cyclin A2 (CCNA2) is a protein that regulates cell‑cycle progression and helps cells divide and grow, and altering its activity in the adrenal gland can produce physiological changes.	It may mimic exercise effects in adrenal tissue possibly by promoting proliferative and metabolic pathways that increase catecholamine production and energy‑handling similar to the stress of physical activity.
PGRMC1	PGRMC1 is a protein that helps cells respond to hormones and stress, and altering its activity could make adrenal glands behave as if they were being exercised.	It might mimic exercise by possibly modulating steroid hormone synthesis and signaling pathways that are also activated during physical activity.
ASAH1	ASAH1 encodes an enzyme that degrades sphingolipids, a type of fat involved in cell membranes and signaling.	It might push intestinal cells away from an exercise‑like state, possibly by reducing sphingolipid signaling that supports metabolic pathways activated by physical activity.
TACSTD2	TACSTD2 is a cell‑surface protein that helps cells stick together and communicate with their surroundings.	Its over‑activity might blunt the metabolic benefits of exercise in white fat by possibly interfering with signaling pathways that promote mitochondrial activity and fatty‑acid oxidation.
CHUK	CHUK is a cellular enzyme that controls inflammation and other signaling pathways, acting like a master switch in many tissues.	It might mimic exercise in kidney tissue by modestly activating NF‑κB signaling, which could drive metabolic and stress‑response changes similar to those seen after physical activity.
NCOA2	NCOA2 is a gene that helps coordinate signals controlling muscle cell growth and metabolism.	It may push cells away from an exercise-like state possibly by weakening the activation of pathways that normally increase energy use and mitochondrial function during activity.
GYPE	GYPE is a gene alteration that appears to shift white‑fat cells away from the healthier, “exercise‑like” metabolic profile.	It may do so by possibly disrupting signaling pathways that normally promote mitochondrial activity and fat‑burning in response to physical activity.
pioglitazone	Pioglitazone is a medication that improves insulin sensitivity in type‑2 diabetes and can also influence brain cell metabolism.	It might push hippocampal cells away from an exercise‑like state possibly by activating PPARγ, which can alter mitochondrial activity and suppress activity‑dependent gene expression.
TMEM156	TMEM156 is a little‑known membrane protein that appears to influence how fat cells behave, and our screen flagged it as a factor that may keep white‑adipose tissue from adopting a more active, exercise‑like state.	It might push cells away from an exercise‑like state possibly by interfering with signaling pathways that normally stimulate mitochondrial biogenesis and fatty‑acid oxidation in adipocytes.
NFKBIZ	NFKBIZ is a gene that helps regulate inflammation and immune responses in cells.	It might push brown‑adipose cells away from an exercise‑like state possibly by increasing inflammatory signaling that suppresses the thermogenic program.
ACO1	ACO1 encodes a protein that regulates iron handling and energy production in cells, and changing its activity could disturb normal colon cell behavior.	Possibly, disrupting ACO1 impairs mitochondrial iron‑sulfur cluster formation, lowering oxidative metabolism and thus moving cells away from the exercise‑like state.
flutamide	Flutamide is a medication that blocks male hormones and is often prescribed for prostate cancer.	It may push heart cells away from an exercise-like state possibly by suppressing androgen‑receptor signaling that supports metabolic and mitochondrial remodeling.
ABT-737	ABT‑737 is a small‑molecule drug that blocks the activity of BCL‑2 family proteins, which normally help cells avoid death.	It could push gastrocnemius cells away from an exercise‑like state possibly by triggering apoptosis or dampening survival pathways that are activated by physical activity.
alvocidib	Alvocidib is a drug that blocks certain enzymes involved in cell growth and is being studied for its effects on heart tissue.	It might push cells away from an exercise-like state possibly by inhibiting CDK9, which reduces transcription of genes needed for metabolic adaptation.
SSTR4	SSTR4 encodes a receptor that helps brain cells respond to signaling molecules, and changing its activity could alter how those cells function.	It might push cells away from an exercise‑like state by weakening somatostatin signaling, thereby reducing activity‑dependent gene expression.
crizotinib	Crizotinib is an FDA‑approved drug that blocks the activity of certain cancer‑related proteins (ALK, ROS1, and MET) and is used to treat some lung cancers. It is being investigated for other effects beyond cancer.	It might mimic exercise by possibly dampening ALK/MET signaling pathways that regulate metabolism and inflammatory responses in blood cells.
ellipticine	Ellipticine is a plant‑derived molecule that can interact with DNA and influence cell growth and survival.	It might mimic exercise in ovarian tissue possibly by activating stress‑responsive pathways that promote mitochondrial function and metabolic remodeling.
brivanib	Brivanib is an investigational drug that blocks VEGF and FGF signals, pathways that control blood‑vessel growth.	It might mimic certain exercise effects in colon tissue possibly by dampening angiogenic signaling, which could alter metabolic and inflammatory responses.
PSMB1	PSMB1 is a protein that helps break down other proteins inside cells, and altering its activity can change how intestinal cells grow and function.	It might mimic exercise effects in the small intestine by possibly modulating protein turnover and signaling pathways that promote cellular remodeling and metabolic adaptation.
PRKACG	PRKACG is a protein that helps control how cells respond to signals that tell them to grow and adapt, and tweaking its activity could make thigh‑muscle cells behave a bit like they do after a workout.	It may mimic exercise by possibly enhancing the cAMP‑PKA signaling pathway, which can boost mitochondrial biogenesis and promote muscle remodeling.
CST3	CST3 (cystatin C) is a small protein in the blood that controls enzymes that break down other proteins, influencing inflammation and tissue remodeling.	It may mimic exercise effects possibly by altering protease activity and downstream inflammatory and metabolic signaling pathways that are also regulated during physical activity.
ML-167	ML-167 is a small‑molecule drug that blocks the release of Wnt signaling proteins and has been shown to induce exercise‑like changes in brown fat cells.	It may mimic exercise by inhibiting Wnt signaling, thereby lifting repression on the PGC‑1α/PRDM16 pathway and promoting mitochondrial biogenesis and thermogenic gene expression.
MAPK15	MAPK15 is a protein that helps cells respond to signals that control growth and metabolism, and it is active in many tissues including the small intestine.	It might mimic exercise effects in the gut by possibly enhancing mitochondrial activity and nutrient‑sensing pathways that are also activated during physical activity.
doramapimod	Doramapimod is an experimental compound that seems to induce changes in testicular tissue resembling those caused by physical exercise.	It may mimic exercise effects possibly by activating AMPK signaling, leading to metabolic and mitochondrial adaptations in testicular cells.
methyl-2,5-dihydroxycinnamate	Methyl-2,5-dihydroxycinnamate is a plant‑derived compound that resembles natural antioxidants and is being studied for its potential health benefits.	It might mimic exercise in ovarian tissue by activating AMPK‑related energy‑sensing pathways and boosting antioxidant defenses.
homoharringtonine	Homoharringtonine is a natural compound derived from the Chinese tree *Cephalotaxus* that blocks protein production in cells and is used as a cancer drug.	It might push spleen cells away from an exercise‑like state by inhibiting the synthesis of key metabolic proteins that are normally up‑regulated during physical activity.
CAY-10594	CAY-10594 is a small‑molecule compound that inhibits a metabolic enzyme, and it has been shown to alter liver gene expression in ways that resemble the effects of physical activity.	It may mimic exercise in liver by possibly activating AMPK‑related pathways that promote fatty‑acid oxidation and mitochondrial biogenesis.
BI-2536	BI‑2536 is a drug that blocks the enzyme PLK1, which helps cells divide and grow.	It possibly pushes kidney cells away from an exercise‑like state by inhibiting PLK1‑driven signaling pathways that normally promote metabolic remodeling during physical activity.
cobimetinib	Cobimetinib is a medication that blocks the MEK protein, primarily used to treat certain cancers.	It might mimic some exercise effects possibly by dampening MAPK signaling, which could trigger metabolic shifts resembling those induced by physical activity.
sirolimus	Sirolimus is an immunosuppressive medication commonly used to prevent organ‑transplant rejection and is being explored for its anti‑aging properties.	It might mimic exercise effects in the spleen by possibly inhibiting mTOR signaling, thereby inducing metabolic and immune‑cell changes reminiscent of physical activity.
vorinostat	Vorinostat is a medication that inhibits histone deacetylases and is used mainly to treat certain cancers.	It might push lung cells away from an exercise‑like state by possibly altering gene‑expression programs that regulate metabolism and stress‑response pathways.
CDK2	CDK2 is a protein that regulates cell division and growth, and tweaking its activity could affect how the adrenal glands respond to stress.	It might mimic exercise effects possibly by modulating cell‑cycle signaling that enhances hormone output and metabolic pathways in adrenal tissue.
entinostat	Entinostat is a medication that inhibits specific enzymes controlling gene activity and is being investigated for its effects beyond cancer treatment.	It might mimic exercise by possibly inhibiting histone deacetylases, thereby enhancing expression of genes that promote mitochondrial function and stress‑response pathways in adrenal tissue.
ASA-404	ASA‑404 is a small‑molecule drug that was originally developed to modulate brain signaling pathways and is being investigated for its potential to enhance brain health.	It may mimic exercise‑like effects in cortical tissue possibly by activating neurotrophic signaling cascades that promote synaptic plasticity and metabolic adaptation.
AKR1C4	AKR1C4 is an enzyme that helps process steroid hormones, and adjusting its activity in heart cells appears to produce changes similar to those seen after regular exercise.	It might mimic exercise by altering local steroid or prostaglandin levels, thereby subtly shifting cardiac energy use and protective signaling pathways.
RPS6KB1	RPS6KB1 is a protein‑building enzyme that helps cells grow and respond to nutrients.	It may push lung cells away from an exercise‑like state by excessively stimulating the mTOR‑driven protein synthesis pathway, which could blunt the metabolic remodeling normally triggered by physical activity.
(2S,3R)-8-(2-cyclohexylethynyl)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-2-(methylaminomethyl)-3,4-dihydro-2H-pyrido[2,3-b][1,5]oxazocin-6-one	A synthetic, chiral molecule featuring a cyclohexylethynyl side chain and multiple functional groups, designed to interact with vascular proteins.	It could possibly mimic exercise by activating endothelial signaling pathways (such as nitric‑oxide synthase) that promote vasodilation in the vena‑cava.
JAK3	JAK3 is a signaling protein that helps immune cells coordinate their responses, influencing how colon cells react to various signals.	Possibly, altering JAK3 activity disrupts cytokine pathways that normally support the metabolic and anti‑inflammatory changes associated with an exercise‑like state, thereby pushing cells away from that condition.
fluphenazine	Fluphenazine is an antipsychotic medication that blocks dopamine receptors and is commonly used to treat schizophrenia.	It may push hippocampal cells away from an exercise-like state possibly by antagonizing D2 dopamine signaling, which could dampen activity‑dependent neuroplastic pathways.
SB-743921	SB-743921 is a small‑molecule compound originally designed to target a specific cellular enzyme and is being studied for its effects on reproductive tissue.	It might mimic aspects of exercise in testes by possibly activating signaling pathways that promote mitochondrial function and energy metabolism.
PDE1B	Reducing PDE1B activity can boost heart cell signaling, potentially improving the heart’s ability to adapt to stress.	Possibly by increasing cAMP/cGMP levels that enhance calcium handling and metabolic pathways in cardiomyocytes.
ALOX15B	ALOX15B is an enzyme that converts fatty acids into bioactive lipids, influencing inflammation and tissue remodeling in the gut.	It could potentially drive colon cells away from an exercise‑like state by lowering the levels of pro‑exercise lipid mediators that support metabolic and anti‑inflammatory signaling.
MLN-4924	MLN‑4924 is an experimental drug that blocks the NEDD8‑activating enzyme, a cellular system that tags proteins for activity and degradation, and is being explored for its effects on muscle metabolism.	It may mimic exercise in the gastrocnemius possibly by promoting mitochondrial biogenesis and altering protein turnover through inhibition of NEDD8‑dependent ubiquitination.
erythromycin-ethylsuccinate	Erythromycin-ethylsuccinate is a chemically modified version of the antibiotic erythromycin that carries an ethylsuccinate group, changing how it interacts with cells.	Possibly by disrupting mitochondrial energy metabolism and the downstream signaling that normally supports exercise‑like transcriptional programs in hippocampal neurons.
danusertib	Danusertib is an experimental drug that blocks specific kinases—enzymes that help control cell signaling and growth.	It might push cells away from an exercise‑like state possibly by inhibiting Aurora kinase pathways that mediate metabolic adaptations to physical activity.
flunarizine	Flunarizine is a calcium‑channel blocker that is commonly used to prevent migraines and treat balance disorders.	It might push testicular cells away from an exercise‑like state by dampening calcium‑dependent signaling pathways that normally activate metabolic and stress‑response programs.
cephaeline	Cephaeline is a plant‑derived alkaloid best known for its vomiting‑inducing effects and is being investigated for its impact on liver cells.	It possibly pushes liver cells away from an exercise‑like metabolic state by disrupting mitochondrial energy production and dampening AMPK signaling.
PCK2	PCK2 is an enzyme that helps cells make energy by turning certain molecules into building blocks for metabolism.	It might push lung cells away from an exercise-like state possibly by altering the balance of metabolic intermediates that signal energy demand.
AZD-8055	AZD‑8055 is a research drug that blocks the activity of mTOR proteins, key regulators of cell growth and metabolism.	It may mimic some exercise effects in the cortex possibly by inhibiting mTORC1/2 signaling, thereby activating pathways that promote neuronal plasticity and energy balance.
ASIC3	ASIC3 is a protein on muscle cells that senses acidic conditions and can affect pain and signaling in the tissue.	It may push cells away from an exercise-like state possibly by disrupting pH‑dependent signaling pathways that normally activate metabolic and growth programs.
alectinib	Alectinib is a medication that blocks the ALK protein and is primarily used to treat specific lung cancers.	It might push adrenal cells away from an exercise‑like state possibly by inhibiting ALK‑driven signaling pathways that support metabolic activation.
ML162	ML162 is a small‑molecule drug that inhibits GPX4, an enzyme that normally shields cells from a specific form of oxidative damage called ferroptosis.	It may mimic exercise by inducing a mild oxidative stress that triggers NRF2‑dependent antioxidant and mitochondrial biogenesis pathways in heart tissue.
MLN-0128	MLN‑0128 is an experimental drug that blocks the activity of the mTOR enzyme, a key regulator of cell growth and metabolism.	It may mimic some effects of exercise in the cortex by possibly reducing mTOR‑driven protein synthesis and thereby promoting metabolic and synaptic remodeling similar to activity‑dependent plasticity.
diethylstilbestrol	Diethylstilbestrol (DES) is a synthetic estrogen once used in pregnancy that was later linked to serious health effects.	It might push kidney cells away from an exercise‑like state possibly by interfering with estrogen‑driven signaling that regulates metabolic and mitochondrial gene expression.
ACSL1	ACSL1 is a gene that encodes an enzyme helping cells turn fatty acids into usable energy, influencing how lung cells manage metabolism.	It may push cells away from an exercise‑like state possibly by altering fatty‑acid processing, thereby limiting the energy supply needed for the heightened metabolic activity seen during exercise.
ZWINT	ZWINT is a protein that helps cells divide and has been shown to activate gut pathways that resemble those triggered by physical activity.	Possibly by influencing Wnt/β‑catenin signaling, ZWINT may boost intestinal cell turnover and metabolic activity in a way that mimics exercise.
PD-0325901	PD‑0325901 is a small‑molecule inhibitor that blocks the MEK enzymes, which are part of a cellular pathway that controls growth and metabolism.	It may mimic exercise in ovarian tissue possibly by dampening MEK/ERK signaling, thereby shifting energy use and stress‑response pathways toward a more “active” state.
ixazomib	Ixazomib is a proteasome‑inhibiting drug, originally approved for treating certain cancers, that can affect protein turnover in many cell types.	It might push cortical cells away from an exercise‑like state possibly by blocking proteasome activity, thereby disrupting the degradation of proteins that regulate activity‑dependent signaling and gene expression.
trichostatin-a	Trichostatin‑A is a drug that blocks enzymes called histone deacetylases, altering how genes are turned on and off.	It might mimic exercise in brown fat by possibly increasing the expression of genes that boost mitochondrial activity and heat production.
MYLK2	MYLK2 encodes a muscle‑type myosin light chain kinase that influences how adrenal cells contract and respond to hormonal cues.	It may push cells away from an exercise‑like state possibly by dampening calcium‑dependent signaling that normally promotes metabolic activation.
maxacalcitol	Maxacalcitol is a synthetic vitamin D analog used to treat certain skin disorders, and it has been observed to affect hormone production in adrenal tissue.	It might mimic exercise effects by activating the vitamin D receptor, which could modulate adrenal steroidogenesis and stress‑response pathways.
SLC13A1	SLC13A1 is a gene that makes a transporter protein that moves sulfate and other small molecules into cells, and tweaking its activity could reproduce some benefits of working out in the calf muscle. Our analysis flagged it as a promising exercise‑mimic target.	It may mimic exercise by possibly raising intracellular sulfate, which could boost metabolic pathways involved in muscle growth and endurance.
efavirenz	Efavirenz is an antiretroviral medication that can change how spleen immune cells act, making them resemble a less‑active, non‑exercise state.	It might push cells away from an exercise‑like state by disrupting mitochondrial function and dampening the signaling pathways that are usually heightened during physical activity.
I-BET-151	I‑BET‑151 is a small‑molecule drug that blocks BET bromodomain proteins, which help turn genes on and off.	It may push ovarian cells away from an exercise‑like state by inhibiting BET‑mediated transcription of genes normally activated by physical activity.
bisindolylmaleimide	Bisindolylmaleimide is a small chemical that blocks certain signaling proteins called protein kinase C, and it’s being studied for its potential health effects.	It might mimic exercise in vena‑cava tissue by possibly reducing PKC‑driven vascular tone, thereby enhancing nitric‑oxide signaling and promoting vasodilation similar to physical activity.
PF-562271	PF-562271 is an experimental drug that blocks the focal adhesion kinase (FAK) enzyme, which helps cells sense and respond to their environment.	It might push cortical cells away from an exercise‑like state possibly by inhibiting FAK signaling, thereby dampening activity‑dependent gene expression.
BMX	BMX is a gene that encodes a signaling enzyme called a non-receptor tyrosine kinase. This entry represents a laboratory gene knockout, which lets researchers examine how loss of BMX changes cell activity.	The signature match motivates testing how BMX loss affects exercise-associated gene expression; its mechanism and physiological effects remain to be established.
TMEM173	TMEM173 (also called STING) is a cellular sensor that detects DNA fragments and triggers immune and metabolic responses, and its activation in kidney cells appears to produce changes similar to those seen after physical activity.	It might mimic exercise by stimulating STING‑dependent signaling pathways that promote mitochondrial biogenesis and anti‑inflammatory remodeling in renal tissue.
withaferin-a	Withaferin‑A is a natural compound from the Ashwagandha plant that has anti‑inflammatory and stress‑protective properties.	It may mimic exercise in gastrocnemius muscle possibly by activating stress‑responsive pathways such as Nrf2 and enhancing mitochondrial biogenesis.
R-547	R-547 is a small‑molecule compound that was found to make white‑fat cells behave more like they do after a workout, such as burning more fat and becoming more metabolically active.	It might mimic exercise by possibly activating AMPK and downstream pathways that boost mitochondrial function and fatty‑acid oxidation in adipocytes.
BEST1	BEST1 is a calcium‑activated chloride channel that helps cells control fluid and ion balance, especially in blood‑vessel walls.	It might mimic exercise effects by boosting calcium‑dependent chloride currents, which could activate vascular signaling pathways similar to those engaged during physical activity.
PSG5	PSG5 is a protein that, when elevated, seems to cause hippocampal brain cells to act less like they do after physical exercise.	Possibly by interfering with signaling pathways that normally promote neurogenesis and metabolic activation.
dinaciclib	Dinaciclib is an experimental drug that blocks proteins called CDKs, which help cells grow and divide.	It may mimic exercise in lung tissue possibly by inhibiting CDK activity, leading to metabolic and anti‑inflammatory changes similar to those triggered by physical activity.
PIGA	PIGA is a gene that helps build a special anchor that tethers many proteins to the cell surface, and alterations in it can change how cells sense their environment.	It might push cells away from an exercise-like state possibly by disrupting GPI‑anchor formation, which could impair surface receptors that transmit mechanical or metabolic cues.
PF-477736	PF‑477736 is a drug that inhibits the checkpoint kinase 1 (Chk1) enzyme, a key regulator of DNA repair and cell‑cycle control.	It might mimic exercise in vastus‑lateralis by possibly triggering stress‑responsive signaling that promotes muscle remodeling and mitochondrial biogenesis.
SDHB	SDHB is a gene that supports the mitochondria’s ability to generate energy, a process that fuels muscle activity.	It might push cells away from an exercise-like state possibly by dampening oxidative metabolism and the downstream signaling that drives exercise‑induced adaptations.
bortezomib	Bortezomib is a cancer medication that blocks the proteasome, the cell’s machinery for breaking down proteins.	It may push heart cells away from an exercise‑like state possibly by preventing degradation of proteins that regulate metabolic and contractile gene programs.
NNC-55-0396	NNC‑55‑0396 is an experimental compound that blocks certain calcium channels in cells, which can change how those cells behave.	It may mimic exercise in colon tissue by reducing calcium‑driven signaling, potentially shifting metabolic and anti‑inflammatory pathways.
GABRR1	GABRR1 encodes a GABA‑type receptor, and changing its activity in the vastus‑lateralis muscle can alter how the tissue responds to physiological signals.	It may push cells away from an exercise‑like state possibly by disrupting inhibitory GABA signaling that normally supports metabolic and contractile adaptations.
spironolactone	Spironolactone is a medication that blocks the hormone aldosterone, helping the body get rid of excess fluid and lower blood pressure.	It might push kidney cells away from an exercise‑like state possibly by disrupting aldosterone‑mediated signaling pathways that normally promote metabolic activation and cellular remodeling.
HSD11B2	HSD11B2 is an enzyme that deactivates cortisol, helping keep hormone levels balanced in the body.	It may push vena‑cava cells away from an exercise‑like state by reducing cortisol clearance, thereby altering stress‑hormone signaling that supports exercise‑associated metabolic pathways.
PF-03758309	PF‑03758309 is an experimental compound that appears to trigger molecular changes in kidney cells similar to those seen after physical exercise.	It may mimic exercise effects by possibly activating AMPK signaling and promoting mitochondrial biogenesis in renal tissue.
mocetinostat	Mocetinostat is a drug that inhibits specific histone deacetylase enzymes, affecting how genes are turned on and off.	It might push cells away from an exercise-like state possibly by altering the expression of metabolic genes that normally respond to physical activity.
ATXN2	ATXN2 is a gene that makes a protein involved in cellular stress responses, and changes in its activity can affect how heart‑related cells behave.	It may push cells away from an exercise‑like state by impairing mitochondrial energy production and calcium signaling, reducing their ability to respond to exercise cues.
perhexiline	Perhexiline is a medication once used for heart problems that works by shifting how cells generate energy.	It might push hippocampal cells away from an exercise‑like state by possibly inhibiting fatty‑acid oxidation and altering mitochondrial metabolism, thereby dampening the metabolic cues that normally promote exercise‑related gene programs.
danazol	Danazol is a synthetic steroid medication sometimes used to treat hormonal disorders and certain cancers.	It might push testicular cells away from an exercise-like state possibly by altering androgen signaling and disrupting the metabolic pathways that normally support activity‑driven gene expression.
indoramin	Indoramin is a prescription medication that relaxes blood vessels to help lower high blood pressure.	It might mimic some effects of exercise in the hippocampus possibly by enhancing cerebral blood flow and stimulating neurotrophic pathways such as BDNF signaling.
GSK-1059615	GSK-1059615 is a small‑molecule drug that blocks key cellular growth and metabolism pathways.	It may push colon cells away from an exercise‑like state by inhibiting PI3K/mTOR signaling, which is thought to mediate many of the metabolic benefits of physical activity.
AT-9283	AT‑9283 is an experimental drug that blocks multiple protein kinases and has been investigated mainly for its anti‑cancer properties.	It might push colon cells away from an exercise‑like state by inhibiting AKT/mTOR signaling pathways that mediate the beneficial metabolic effects of exercise.
SB-525334	SB‑525334 is a compound that blocks the activity of a key protein in the TGF‑β signaling pathway, which helps regulate tissue growth and repair.	It may push gastrocnemius cells away from an exercise‑like state possibly by inhibiting TGF‑β‑mediated SMAD signaling that is needed for the transcriptional program of muscle adaptation.
MST-312	MST‑312 is a small‑molecule drug that our screen suggests may shift muscle cells in the calf away from the gene‑expression patterns normally seen after exercise.	It might push cells away from an exercise-like state possibly by inhibiting telomerase activity, thereby altering signaling pathways that normally promote the exercise‑induced transcriptional program.
CDK7	CDK7 is a key regulator that helps cells read their DNA, and adjusting its activity could enhance the lung’s capacity for repair and adaptation.	It might mimic exercise by possibly reprogramming transcription of genes that govern mitochondrial function and stress‑response pathways in lung tissue.
clindamycin	Clindamycin is an antibiotic often prescribed for bacterial infections of the skin, lungs, and soft tissues.	It might push heart cells away from an exercise-like state possibly by disrupting mitochondrial protein synthesis, leading to reduced cellular energy production.
NVP-TAE684	NVP‑TAE684 is an experimental drug that blocks the ALK protein, originally investigated for cancer treatment, and has been found to shift heart cells away from an exercise‑like state.	Possibly by inhibiting ALK‑driven signaling pathways that normally promote the metabolic and growth programs associated with cardiac exercise adaptation.
HSPA5	HSPA5 is a protein that helps cells cope with stress, and boosting its activity could make colon cells behave as if they've been exercised.	It might mimic exercise effects by possibly enhancing cellular protein‑folding and stress‑response pathways that are also activated during physical activity.
HOXA13	HOXA13 is a developmental gene, and tweaking its activity can cause changes in the testes that look similar to some effects of physical exercise.	It might mimic exercise possibly by altering growth‑factor signaling that boosts cellular turnover and metabolic activity in testicular tissue.
triamcinolone	Triamcinolone is a prescription steroid that reduces swelling and pain by dampening the body's immune response.	It might mimic some exercise effects in colon tissue possibly by suppressing inflammatory signaling pathways that are also down‑regulated during physical activity.
KIR3DL1	KIR3DL1 is a receptor found on certain immune cells that can influence brain inflammation and signaling.	It might mimic exercise effects in the hippocampus possibly by modulating immune‑brain communication and enhancing neuroprotective pathways.
ruboxistaurin	Ruboxistaurin is a medication that inhibits the protein kinase C‑β enzyme and has been investigated for treating complications of diabetes.	It might mimic exercise in spleen tissue possibly by dampening oxidative stress and modulating immune‑cell signaling through PKC‑β inhibition.
SGI-1776	SGI‑1776 is a small‑molecule drug originally designed to inhibit the PIM1 kinase, and researchers are exploring its broader health impacts.	It might mimic exercise in liver by possibly activating AMPK signaling pathways that enhance energy metabolism.
MI-2	MI-2 is a compound that blocks a key signaling enzyme, and it appears to dampen the activity of brown‑fat cells.	It may push cells away from an exercise‑like state possibly by inhibiting the pathway that normally stimulates thermogenic gene expression.
resiquimod	Resiquimod is a drug that activates the immune system by mimicking viral RNA, and is being studied for its anti‑cancer and antiviral effects.	It might mimic exercise in colon tissue possibly by stimulating Toll‑like receptors that increase anti‑inflammatory cytokines and promote gut‑muscle signaling pathways.
fluvastatin	Fluvastatin is a cholesterol‑lowering medication in the statin family, commonly prescribed to reduce heart disease risk.	It might push white‑adipose cells away from an exercise‑like state possibly by inhibiting the mevalonate pathway, which reduces prenylation of proteins needed for mitochondrial biogenesis.
FFAR2	FFAR2 is a receptor that detects short‑chain fatty acids, compounds produced by gut microbes and found in certain foods.	It might mimic exercise in lung tissue possibly by activating anti‑inflammatory signaling and boosting mitochondrial activity via short‑chain fatty‑acid pathways.
NVP-BEZ235	NVP‑BEZ235 is a drug that blocks two key signaling pathways, PI3K and mTOR, which are involved in cell growth and metabolism.	It might mimic exercise in the cortex by possibly reducing mTOR activity, thereby promoting autophagy and metabolic remodeling similar to the effects of physical activity.
JTC-801	JTC‑801 is a small‑molecule drug that blocks κ‑opioid receptors and has been observed to diminish the molecular signatures of an exercised vastus lateralis muscle.	It may push cells away from an exercise‑like state possibly by suppressing κ‑opioid‑mediated signaling pathways that normally activate mitochondrial biogenesis and muscle remodeling.
vinblastine	Vinblastine is a chemotherapy drug that blocks cell division by interfering with the cell’s internal scaffolding.	It might push cells away from an exercise-like state possibly by disrupting microtubule dynamics needed for muscle signaling and remodeling.
BRD2	BRD2 is a protein that helps regulate gene activity in cells, including those in brown fat that generate heat.	It might push cells away from an exercise-like state by dampening the expression of genes that promote mitochondrial biogenesis and thermogenic pathways.
BAY-61-3606	BAY‑61‑3606 is a small‑molecule drug that blocks the activity of the SYK enzyme, a key player in cellular signaling.	It may push adrenal cells away from an exercise‑like state by possibly dampening SYK‑dependent pathways that support the metabolic and transcriptional programs linked to physical activity.
CHEK1	CHEK1 is a protein that helps cells repair DNA and regulate their division, acting like a quality‑control checkpoint.	It might mimic exercise effects in female heart tissue by possibly boosting stress‑responsive signaling that improves cardiac metabolism and repair.
AMG-232	AMG‑232 is an experimental compound that blocks the MDM2 protein, thereby freeing the tumor‑suppressor p53 to become more active in cells.	It may mimic exercise by possibly activating p53‑driven pathways that enhance mitochondrial function and muscle remodeling.
XL-888	XL-888 is an experimental compound that seems to induce brain changes resembling those produced by regular physical exercise.	It could possibly mimic exercise by stimulating neurotrophic signaling and enhancing mitochondrial activity in male cortical tissue.
gefitinib	Gefitinib is a cancer medication that blocks the EGFR protein, and our screen indicates it may shift lung cells in women away from a healthy, exercise‑like state.	It might achieve this by inhibiting EGFR signaling, thereby dampening the metabolic and mitochondrial changes normally promoted by exercise.
rosiglitazone	Rosiglitazone is a medication that activates the PPAR‑γ receptor to improve insulin sensitivity and is commonly used to treat type 2 diabetes.	It may mimic exercise in female colon tissue possibly by stimulating PPAR‑γ–driven mitochondrial biogenesis and fatty‑acid oxidation pathways.
sonidegib	Sonidegib is a medication that blocks the Hedgehog signaling pathway and is approved for treating some types of cancer.	It might mimic exercise in female vastus lateralis possibly by inhibiting Hedgehog signaling, which could promote muscle fiber remodeling and a shift toward a more oxidative, endurance‑like phenotype.
TYMS	TYMS is an enzyme that helps cells build DNA, supporting growth and repair processes in the body.	It might mimic exercise effects in the female hippocampus possibly by boosting DNA synthesis and metabolic pathways that promote neurogenesis.
lopinavir	Lopinavir is an antiviral medication often used in combination therapy to treat HIV infection, working by blocking a key viral enzyme.	It might push gastrocnemius muscle cells away from an exercise-like state possibly by impairing mitochondrial energy production or disrupting signaling pathways that regulate muscle metabolism.
AZD-8330	AZD-8330 is an experimental drug that blocks a key signaling protein called MEK, which is involved in cell growth and metabolism.	It might mimic exercise in female kidney tissue by dampening MEK/ERK activity, which could indirectly activate AMPK‑PGC‑1α pathways that drive mitochondrial biogenesis and metabolic remodeling.
lawsone	Lawsone is a natural yellow pigment from the henna plant that can influence how cells behave.	It may push cortical cells away from an exercise‑like state possibly by disrupting mitochondrial energy production or oxidative signaling pathways.
ZSTK-474	ZSTK-474 is an experimental compound that blocks PI3K enzymes, which help regulate cell growth and metabolism.	It may mimic exercise in male small‑intestine tissue possibly by dampening PI3K/Akt signaling, thereby activating AMPK‑driven metabolic pathways similar to those induced by physical activity.
5-nonyloxytryptamine	5‑nonyloxytryptamine is a synthetic serotonin‑like molecule that can influence signaling in the brain and immune system.	It may shift spleen cells away from an exercise‑like state possibly by activating serotonin receptors that modulate inflammatory and metabolic pathways.
KU-0063794	KU-0063794 is a small‑molecule drug that blocks a key signaling protein, and in our screen it appeared to move cells in female vena‑cava tissue away from a gene‑expression pattern typical of exercise.	It may push cells away from an exercise‑like state possibly by dampening mTORC1‑driven metabolic and mitochondrial remodeling.
idelalisib	Idelalisib is a medication that blocks the PI3‑kinase delta enzyme and is used to treat some blood cancers.	It may push muscle cells away from an exercise-like state possibly by inhibiting PI3K‑δ signaling, thereby reducing Akt/mTOR activity that supports the metabolic and growth responses to physical activity.
amikacin	Amikacin is a strong antibiotic used to treat serious bacterial infections.	It might mimic exercise effects possibly by activating stress‑responsive signaling pathways in spleen immune cells, leading to metabolic reprogramming.
VANGL2	VANGL2 is a gene that helps cells coordinate their orientation and movement, playing a key role in tissue development and organization.	It might push adrenal cells away from an exercise‑like state possibly by disrupting planar cell polarity signaling that normally promotes metabolic remodeling.
PDS5A	PDS5A is a gene that helps organize DNA and can influence how brown‑fat cells function.	It may push cells away from an exercise‑like state by loosening chromatin at metabolic genes, thereby lowering mitochondrial activity and thermogenic gene expression.
KMT2B	KMT2B is a gene that helps regulate how DNA is packaged, and altering it may reduce the brain’s exercise‑like response in female hippocampus tissue.	It could possibly push cells away from an exercise‑like state by disrupting histone methylation and lowering expression of activity‑dependent genes.
6-(1,3-benzodioxol-5-yl)-N-methyl-N-[(2-methyl-4-thiazolyl)methyl]-4-quinazolinamine	This is a synthetic small‑molecule that combines a benzodioxole ring with a thiazole‑linked quinazoline core and a methylated amine group, and it is being studied for its effects on liver cells.	It might push liver cells away from an exercise‑like state by dampening AMPK activation or other energy‑sensing pathways, thereby reducing mitochondrial oxidative metabolism.
PKM	PKM is an enzyme that helps cells convert glucose into energy, playing a major role in muscle metabolism.	It might push cells away from an exercise-like state possibly by shifting glycolytic flux and dampening the metabolic cues that normally promote exercise‑associated gene programs.
estradiol	Estradiol is a natural hormone that regulates the growth and function of female reproductive organs, including the ovaries.	It might mimic exercise effects in ovarian tissue possibly by activating estrogen receptors that influence mitochondrial activity and metabolic pathways similar to those engaged during physical activity.
CVF-SUMO-11	CVF‑SUMO‑11 is a small‑molecule that seems to induce changes in the male small intestine resembling those caused by regular physical activity.	It might mimic exercise by altering SUMO‑dependent modification of metabolic regulators, thereby boosting mitochondrial function in intestinal cells.
BMS-345541	BMS‑345541 is a small‑molecule drug that blocks a key enzyme involved in inflammation, and it has been found to trigger changes in brown fat that resemble those seen after exercise.	It may mimic exercise effects in brown adipose tissue possibly by dampening IKK‑β‑mediated inflammatory signaling, thereby enhancing AMPK activation and promoting thermogenic gene expression.
clioquinol	Clioquinol is a metal‑binding compound once used as an antifungal and antibacterial agent, but it is no longer widely prescribed.	It might push lung cells away from an exercise‑like state possibly by disrupting zinc‑dependent signaling pathways that help sustain aerobic metabolism.
WDR87	WDR87 is a gene whose alteration seems to make fat cells in female white‑adipose tissue behave less like they do after exercise.	It might push cells away from an exercise‑like state possibly by interfering with signaling pathways that control mitochondrial activity and lipid metabolism.
fenretinide	Fenretinide is a synthetic vitamin A‑related compound that has been studied for its anti‑cancer and metabolic effects.	It might mimic exercise in adrenal tissue possibly by activating retinoic‑acid‑responsive genes that enhance mitochondrial function and lipid oxidation.
phorbol-myristate-acetate	Phorbol‑myristate‑acetate (PMA) is a laboratory chemical that mimics signals which normally activate immune cells, and it’s often used to stimulate cells in research experiments.	It might push muscle cells away from an exercise‑like state possibly by hyper‑activating protein kinase C pathways that override the normal signaling that promotes metabolic and structural adaptations to physical activity.
ABCA7	ABCA7 is a gene that helps transport lipids and cholesterol out of cells, influencing how fat tissue stores and processes fats.	Possibly by decreasing lipid efflux and modulating inflammatory pathways, it may diminish the exercise‑like metabolic programming in female white‑adipose cells.
buparlisib	Buparlisib is an experimental drug that blocks the PI3K enzyme, a key regulator of cell growth and metabolism, and is being studied for its effects on various tissues.	It may mimic exercise in adrenal female tissue possibly by inhibiting PI3K signaling, thereby reproducing the metabolic stress and catecholamine responses typically triggered by physical activity.
PUS7	PUS7 is an enzyme that adds a chemical modification called pseudouridine to RNA, and changing its activity in fat cells can lead to changes that resemble the effects of exercise.	Possibly, altering PUS7 reshapes the transcriptome to boost mitochondrial function and fatty‑acid oxidation, thereby mimicking exercise‑induced metabolic remodeling.
NFE2L3	NFE2L3 is a gene that helps regulate how cells handle fat and respond to stress.	It might mimic exercise effects by possibly boosting fatty‑acid oxidation and lowering inflammation in white‑adipose tissue.
selumetinib	Selumetinib is a medication that inhibits the MEK protein, a key player in cell growth pathways, and is currently used in certain cancer treatments.	It might mimic exercise in female hypothalamic tissue possibly by dampening MEK‑ERK signaling, which could modulate neuropeptide pathways that regulate energy balance.
1-[(8S,9S,10R)-10-(hydroxymethyl)-9-[4-(4-methoxyphenyl)phenyl]-1,6-diazabicyclo[6.2.0]decan-6-yl]-2-pyridin-4-ylethanone	The compound is a synthetic, bicyclic molecule featuring a hydroxymethyl group and a methoxy‑phenyl side chain, created to engage specific cellular proteins.	It may mimic exercise in male gastrocnemius tissue possibly by activating metabolic regulators such as AMPK or PGC‑1α through binding to an as‑yet‑unidentified target.
UNC-669	UNC-669 is a small compound that seems to turn on brain genes in a way that resembles the molecular changes seen after physical exercise.	It may mimic exercise possibly by modestly activating signaling pathways that promote neurogenesis and metabolic remodeling in hippocampal neurons.
BIBX-1382	BIBX‑1382 is a small‑molecule inhibitor that, in laboratory studies, triggers changes in female adrenal tissue that look similar to the hormonal and metabolic shifts seen after exercise.	It may mimic exercise possibly by blocking FGFR signaling, which could boost catecholamine production and promote metabolic remodeling akin to that triggered by physical activity.
PABPN1	PABPN1 is a gene‑regulating protein that helps process and stabilize messenger RNA in cells.	It may push brown‑fat cells away from an exercise‑like state possibly by altering RNA processing of metabolic genes, dampening their activation.
brefeldin-a	Brefeldin A is a natural compound that blocks protein transport within cells, disrupting normal cellular organization.	Possibly, it pushes heart cells away from an exercise-like state by impairing Golgi‑mediated secretion of signaling factors that drive metabolic and structural adaptations to exercise.
MMP15	MMP15 is an enzyme that remodels the tissue scaffolding around cells, helping them adapt their shape and connections.	It might mimic exercise in female brown‑adipose tissue possibly by enhancing extracellular‑matrix turnover, which could promote mitochondrial activity and thermogenic gene expression.
CAM-9-027-3	CAM-9-027-3 is a small‑molecule compound that our screen flagged as likely to move hippocampal cells away from the gene‑expression profile typical of an exercised brain.	It may do so possibly by dampening activity‑dependent signaling pathways that normally promote neurogenesis and metabolic remodeling.
ALDH5A1	ALDH5A1 is an enzyme that helps break down a brain‑derived chemical called GABA, and changing its activity may produce benefits similar to those seen after exercise in female kidney tissue.	It might mimic exercise effects possibly by modulating GABA‑related metabolic pathways that reduce oxidative stress and improve cellular energy balance.
SR-33805	SR-33805 is a drug‑like molecule that seems to drive thigh‑muscle cells away from the healthy, active state normally induced by exercise.	Possibly it disrupts signaling pathways that promote mitochondrial growth and muscle remodeling, thereby dampening the exercise‑like cellular program.
CYLD	CYLD is a gene that regulates protein removal and inflammation, influencing how cells respond to metabolic signals.	It might push brown‑fat cells away from an exercise‑like state possibly by impairing signaling pathways that activate thermogenic and oxidative programs.
NVP-BGJ398	NVP‑BGJ398 is an experimental drug that blocks the FGFR protein, a key driver of cell growth signals.	It might push liver cells away from an exercise-like metabolic state by inhibiting FGFR signaling that normally promotes fatty‑acid oxidation and mitochondrial activity.
digoxin	Digoxin is a drug commonly prescribed to strengthen heart contractions and control irregular heartbeats.	It might push kidney cells away from an exercise-like state by possibly inhibiting sodium‑potassium ATPase activity, leading to altered cellular ion balance and metabolic signaling.
ASL	ASL (argininosuccinate lyase) is a key enzyme in the urea cycle that helps remove excess nitrogen from cells.	Possibly, reducing ASL activity could lower nitric‑oxide levels and disrupt signaling pathways that normally sustain an exercise‑like metabolic state in adrenal male tissue.
torin-2	Torin‑2 is a small‑molecule drug that blocks the activity of the mTOR proteins, which regulate cell growth and metabolism.	It might mimic exercise in male testicular tissue by dampening mTOR signaling, thereby promoting metabolic and autophagic pathways that are normally activated by physical activity.
devazepide	Devazepide is a drug that blocks a stomach receptor involved in controlling appetite and digestion.	It might mimic exercise effects possibly by modulating gut hormone signaling that influences metabolic pathways linked to energy expenditure.
chrysin	Chrysin is a natural plant compound found in honey and passionflower that has antioxidant properties.	It may mimic exercise in ovarian tissue possibly by activating AMPK signaling and enhancing mitochondrial function.
1-(4-fluorophenyl)-3-[(3S,9R,10R)-12-[(2R)-1-hydroxypropan-2-yl]-9-[[(4-methoxyphenyl)methyl-methylamino]methyl]-3,10-dimethyl-13-oxo-2,8-dioxa-12-azabicyclo[12.4.0]octadeca-1(14),15,17-trien-16-yl]urea	This compound is a specially designed, multi‑ring organic molecule that includes a fluorinated phenyl group and several oxygen‑ and nitrogen‑containing rings.	It may mimic exercise in white adipose tissue by possibly activating AMPK signaling through indirect inhibition of phosphodiesterases, leading to increased fatty‑acid oxidation.
benzoxiquine	Benzoxiquine is a small chemical compound that has been investigated for its ability to influence cellular metabolism in the kidney.	It may mimic some effects of exercise by possibly activating AMPK and promoting mitochondrial activity in kidney cells.
GSK-461364	GSK‑461364 is an experimental drug that blocks a protein called PLK1, and early screening suggests it may produce some of the same beneficial changes in thigh muscle that exercise does.	It might mimic exercise by possibly activating pathways that promote muscle remodeling and mitochondrial function through PLK1 inhibition.
(2S,3S,4R)-3-[4-(2-cyclohexylethynyl)phenyl]-4-(hydroxymethyl)-2-azetidinecarbonitrile	This is a lab‑made small molecule featuring a four‑membered azetidine ring, a nitrile group, and a bulky cyclohexylethynyl‑phenyl side chain, created for biological testing.	It could push lung cells away from an exercise‑like state possibly by disrupting signaling pathways that control mitochondrial metabolism or oxidative‑stress responses.
podophyllotoxin	Podophyllotoxin is a plant‑derived compound best known for its use in cancer drugs, but it also shows biological activity in many tissues.	It might mimic exercise in male small‑intestine by modestly disrupting microtubule organization, which could trigger stress‑responsive pathways that enhance cellular metabolism and turnover.
8-(2-Hydroxy-3-methoxy-3-methylbutyl)-7-methoxy-1-benzopyran-2-one	A chemically modified flavonoid resembling a plant pigment, often found in herbal extracts.	It might push heart cells away from an exercise‑like state by interfering with AMPK activation and calcium signaling, thereby dampening metabolic activity.
fludroxycortide	Fludroxycortide is a synthetic steroid cream that reduces inflammation and is used to treat skin conditions.	It might push lung cells away from an exercise‑like state possibly by activating glucocorticoid receptors that suppress metabolic and mitochondrial gene programs.
epoxycholesterol	Epoxycholesterol is a chemically altered version of cholesterol that can influence cell signaling and hormone pathways.	It might push testicular cells away from an exercise-like state possibly by disrupting androgen receptor signaling or altering mitochondrial metabolism.
TTNPB	TTNPB is a synthetic molecule that binds to retinoic acid receptors, modulating gene activity in cells.	It may mimic exercise in male adrenal tissue by possibly stimulating RAR‑driven pathways that enhance mitochondrial function and stress‑response gene programs.
CELA2A	CELA2A is a gene that produces an enzyme that helps break down proteins, and it is expressed in many tissues including fat.	It might push fat cells away from an exercise-like state possibly by altering extracellular matrix remodeling, which could dampen signals that normally boost mitochondrial function.
BUB1	BUB1 is a protein that regulates cell division, and tweaking its activity in female lung tissue can create changes that resemble those observed after physical exercise.	It may mimic exercise possibly by adjusting cell‑cycle control pathways that affect tissue remodeling and metabolic signaling.
CD86	CD86 is a protein on immune cells that helps them communicate and can trigger inflammation.	It might push white‑adipose cells away from an exercise‑like state possibly by increasing inflammatory signaling that interferes with the metabolic pathways normally activated by physical activity.
ACVR1C	A targeted alteration of the ACVR1C gene appears to produce changes in male calf muscle that resemble those seen after regular exercise.	It may mimic exercise effects possibly by modulating signaling pathways that regulate muscle growth and metabolism.
BIX-01294	BIX‑01294 is a small‑molecule inhibitor that blocks the activity of the histone‑methyltransferase G9a, a protein that adds chemical tags to DNA‑associated proteins and can change how genes are turned on or off. In our screen, it appeared to move hypothalamic cells in male tissue away from a gene‑expression pattern that resembles the effects of regular exercise.	It might push cells away from an exercise‑like state possibly by reducing H3K9 dimethylation, thereby altering the expression of metabolic and neuropeptide genes that normally respond to physical activity.
duloxetine	Duloxetine is a prescription medication that increases serotonin and norepinephrine activity and is commonly used for depression and chronic pain.	It may push muscle cells away from an exercise-like state possibly by altering serotonin/norepinephrine signaling, which could dampen sympathetic activation and change metabolic gene programs.
GSK-2110183	GSK‑2110183 is an experimental small‑molecule drug that blocks a specific cellular signaling protein and is being explored for health‑promoting effects.	It may mimic exercise in female colon tissue possibly by activating AMPK‑dependent metabolic pathways that are also stimulated by physical activity.
SA-247615	SA-247615 is a drug‑like compound that appears to make female thigh‑muscle cells act as though they have been exercised.	It possibly mimics exercise by modestly activating energy‑sensing pathways such as AMPK, thereby triggering similar gene‑expression programs.
geldanamycin	Geldanamycin is a natural antibiotic‑derived molecule that influences how cells manage stress and protein folding.	It may mimic aspects of exercise by inhibiting the Hsp90 chaperone, thereby activating stress‑responsive and metabolic pathways that are also engaged during physical activity.
DBH	DBH is an enzyme that converts dopamine into norepinephrine, a hormone that helps the body respond to stress and activity.	It might mimic exercise by possibly raising norepinephrine signaling in muscle, which could activate metabolic pathways and remodeling similar to those triggered by physical activity.
fluoxetine	Fluoxetine is a prescription antidepressant that raises serotonin levels in the brain and is often used to treat depression and anxiety; it is commonly known by the brand name Prozac.	It might push hypothalamic cells away from an exercise-like state possibly by altering serotonin signaling that interferes with metabolic gene programs linked to physical activity.
EMF-sumo1-39	EMF‑sumo1‑39 is a small molecule that blocks the attachment of the SUMO‑1 tag to proteins in heart cells, a process that can affect how those cells function.	It may mimic exercise by possibly enhancing metabolic and stress‑responsive pathways that are normally up‑regulated during physical activity.
belinostat	Belinostat is a medication that inhibits histone deacetylase enzymes, changing gene activity patterns and is primarily investigated as an anti‑cancer therapy.	It may push colon cells away from an exercise‑like state possibly by raising acetylation of genes that dampen metabolic pathways normally enhanced by physical activity.
spiramide	Spiramide is a naturally occurring compound found in certain marine sponges that is being explored for its potential health‑boosting properties.	It might mimic aspects of exercise in male kidney tissue possibly by enhancing mitochondrial function and activating cellular stress‑response pathways.
LY-294002	LY-294002 is a laboratory chemical that blocks a key enzyme in cell signaling and is commonly used to study how cells respond to various stimuli.	It might mimic some effects of exercise in the male hippocampus by possibly inhibiting PI3‑kinase signaling, thereby shifting neuronal metabolism toward pathways activated during physical activity.
CP-724714	CP‑724714 is a small‑molecule drug that blocks the HER2 protein, a key driver of cell growth that is also targeted in some cancers.	It might mimic exercise in male heart tissue possibly by inhibiting HER2, which could activate AMPK signaling and shift cardiac metabolism toward a more oxidative, exercise‑like state.
ER-27319	ER-27319 is a synthetic small‑molecule that appears to disrupt normal metabolic signaling in the female small intestine, steering cells away from the beneficial, exercise‑like state.	It may do so by possibly inhibiting AMPK activation and reducing mitochondrial oxidative capacity, thereby diminishing the cellular pathways that mimic exercise.
PF-05212384	PF-05212384 is an experimental drug that blocks key growth signals inside cells, and it was identified as likely to move cells away from a state resembling the effects of exercise in female vena-cava tissue.	It may push cells away from an exercise‑like state possibly by inhibiting PI3K/mTOR signaling, which dampens the metabolic and mitochondrial pathways normally activated by exercise.
trifluoperazine	Trifluoperazine is a medication first developed as an antipsychotic that influences dopamine and calcium‑related signaling in cells.	It might mimic some exercise‑related effects in male liver by possibly inhibiting calmodulin‑dependent pathways that regulate metabolic gene networks similar to those activated during physical activity.
COPA	COPA is a cellular “shipping” protein that controls the movement of molecules inside cells, and tweaking its activity can shift how gut cells function.	It might mimic exercise by possibly affecting the trafficking of nutrient transporters and signaling pathways that regulate intestinal metabolic and structural remodeling.
NPC26	NPC26 is a genetic perturbation that seems to diminish the exercise‑related benefits normally seen in brain cells of the female hippocampus.	Possibly, it interferes with activity‑dependent signaling pathways that drive neurogenesis, causing cells to shift away from an exercise‑like state.
TRIM46	TRIM46 is a neuronal protein that helps organize the internal scaffolding of brain cells.	It may push cells away from an exercise‑like state possibly by disrupting microtubule architecture and weakening activity‑dependent signaling in hippocampal neurons.
volasertib	Volasertib is a medication that blocks a key protein (PLK1) required for cells to divide, and it has been investigated mainly as a cancer treatment.	It might push liver cells away from an exercise-like state possibly by inhibiting PLK1, which could disrupt cell‑cycle–linked metabolic signaling that normally supports exercise‑induced benefits.
canertinib	Canertinib is a drug that blocks several growth‑factor receptors and is being investigated as a cancer therapy.	It might push adrenal cells away from an exercise‑like state possibly by inhibiting EGFR‑family signaling that normally promotes metabolic programs linked to physical activity.
TAK-715	TAK‑715 is a small‑molecule drug that blocks the activity of a protein called p38 MAPK, a key regulator of how cells respond to stress and physical activity.	It may push small‑intestine female cells away from an exercise‑like state by inhibiting p38‑MAPK signaling, which could reduce the activation of metabolic pathways normally stimulated by exercise.
palbociclib	Palbociclib is a drug that blocks a key protein (CDK4/6) needed for cells to divide, and it’s used mainly to treat certain breast cancers.	It might push muscle cells away from an exercise‑like state possibly by inhibiting CDK4/6‑driven signaling pathways that are normally activated during physical activity.
parthenolide	Parthenolide is a natural compound from the feverfew plant that has anti‑inflammatory effects and is being explored for metabolic health benefits.	It may mimic exercise in male brown‑adipose tissue possibly by modestly activating AMPK and downstream pathways that boost mitochondrial activity and thermogenic gene expression.
trametinib	Trametinib is a cancer medication that blocks the MEK protein, interfering with a signaling pathway often overactive in tumors.	It may mimic exercise effects in female hypothalamus by dampening MAPK/ERK signaling, which could trigger neuronal and metabolic changes similar to those seen after physical activity.
NSDHL	NSDHL is a gene involved in making cholesterol, a key building block for cell membranes and signaling molecules.	It might push cells away from an exercise‑like state possibly by lowering cholesterol production, which could impair membrane remodeling and metabolic signaling needed for exercise adaptations.
hexachlorophene	Hexachlorophene is an antimicrobial chemical once used in soaps and antiseptics that can affect cellular processes in muscle tissue.	It might push muscle cells away from an exercise-like state possibly by impairing mitochondrial energy production and altering lipid signaling pathways.
oncrasin-1	Oncrasin-1 is a small‑molecule compound first identified for its anti‑cancer properties, now being examined for its effects on vascular tissue function.	It may push cells away from an exercise‑like state possibly by disrupting signaling pathways that normally drive metabolic and structural remodeling during physical activity.
deoxycholic-acid	Deoxycholic acid is a bile acid involved in fat digestion that can also act as a signaling molecule influencing immune and metabolic processes.	It might push spleen cells away from an exercise‑like state possibly by activating inflammatory pathways that oppose the beneficial signaling triggered by physical activity.
equol	Equol is a compound produced when gut bacteria break down soy isoflavones, and it can act like a weak estrogen in the body. It is often studied for its potential health effects on hormone balance and metabolism.	It might push spleen cells away from an exercise-like state possibly by modulating estrogen receptor signaling that interferes with the metabolic pathways activated by physical activity.
daunorubicin	Daunorubicin is a chemotherapy medication that interferes with DNA in cancer cells, and our screen suggests it may also produce changes in blood RNA similar to those seen after exercise in men.	It might mimic exercise effects possibly by inducing stress‑responsive signaling pathways that alter mitochondrial and inflammatory gene expression in blood cells.
amsacrine	Amsacrine is a chemotherapy drug that interferes with DNA processing in cancer cells.	It might mimic exercise in brown‑adipose tissue possibly by activating DNA‑damage‑responsive pathways that promote mitochondrial biogenesis and thermogenic gene expression.
OTS-167	OTS‑167 is a small‑molecule drug that blocks a protein important for cell division and is being investigated as a cancer therapy.	It might mimic exercise in female cortical tissue possibly by activating signaling pathways that boost neuronal metabolism and plasticity in a way similar to physical activity.
idarubicin	Idarubicin is a chemotherapy medication used to treat certain cancers, working by damaging DNA in rapidly dividing cells.	It may possibly push cells away from an exercise-like state by disrupting mitochondrial function and altering the expression of genes that regulate metabolic and stress‑response pathways.
2-methoxy-N-[(1-methyl-2-benzimidazolyl)methyl]aniline	2‑Methoxy‑N‑[(1‑methyl‑2‑benzimidazolyl)methyl]aniline is a small synthetic compound that combines an aniline core with a methoxy group and a benzimidazole ring.	It might mimic aspects of exercise in female blood‑RNA by possibly influencing metabolic‑stress signaling pathways (e.g., AMPK activation) that alter gene‑expression patterns.
tozasertib	Tozasertib is an experimental drug that blocks enzymes called Aurora kinases, which are important for cell division.	It might push heart cells away from an exercise-like state possibly by disrupting Aurora‑kinase signaling that regulates metabolic and structural remodeling in response to physical activity.
everolimus	Everolimus is a medication that inhibits the mTOR protein and is approved for treating some cancers and preventing organ‑transplant rejection.	It might mimic exercise in male hippocampus tissue by possibly dampening mTOR activity, thereby activating cellular stress and neuroplasticity pathways similar to those induced by physical activity.
clofarabine	Clofarabine is a chemotherapy medication that, according to our screen, could induce brain‑cell changes in the female hippocampus similar to those seen after physical exercise.	It may mimic exercise possibly by activating neurotrophic signaling pathways such as BDNF and boosting mitochondrial function in hippocampal neurons.
A-443654	A-443654 is a small‑molecule drug that blocks AKT, a key protein that regulates cell growth and metabolism, and is being explored for cancer and metabolic research.	It may push spleen cells away from an exercise‑like state by inhibiting AKT signaling, thereby reducing the metabolic and stress‑response pathways normally activated by exercise.
VU-0413238-1	VU‑0413238‑1 is a small molecule studied by measuring changes in gene activity in treated cells. Researchers compare these laboratory profiles with biological patterns, such as an exercise-response signature.	It may mimic exercise by modestly activating AMPK signaling, which could increase fatty‑acid oxidation and mitochondrial activity in the liver.
tanespimycin	Tanespimycin is a drug originally developed to block a protein that helps cancer cells grow, and it’s now being explored for other health effects.	It might mimic exercise possibly by inhibiting Hsp90, which could activate cellular stress‑response pathways that resemble those triggered by physical activity in lung tissue.
gestrinone	Gestrinone is a synthetic steroid drug that mimics hormones and is sometimes used to treat conditions like endometriosis.	It might push adrenal male cells away from an exercise‑like state possibly by interfering with androgen‑receptor signaling that supports metabolic activation.
AMY2B	AMY2B encodes an enzyme that helps digest starch, and changing its activity in female kidney tissue produces changes that look similar to those seen after exercise.	It could possibly mimic exercise by altering glucose handling and activating metabolic pathways that boost mitochondrial activity and reduce oxidative stress.
zardaverine	Zardaverine is a drug that blocks certain enzymes called phosphodiesterases, raising levels of signaling molecules inside cells.	It might mimic exercise in ovarian tissue possibly by increasing cAMP/PKA signaling that promotes metabolic and vascular changes similar to those triggered by physical activity.
hydroflumethiazide	Hydroflumethiazide is a prescription diuretic that helps the body eliminate excess fluid and lower blood pressure.	It might mimic exercise in female white‑adipose tissue possibly by activating AMPK pathways, which could boost fatty‑acid oxidation and induce a browning‑like metabolic shift.
tibolone	Tibolone is a synthetic hormone commonly prescribed for menopausal symptoms, and in male white‑adipose tissue it may counteract the healthy cellular changes normally triggered by exercise.	It might push cells away from an exercise-like state possibly by activating estrogen receptors that dampen fatty‑acid oxidation and mitochondrial biogenesis pathways.
I-BET-762	I‑BET‑762 is a small‑molecule drug that inhibits BET bromodomain proteins, which read epigenetic marks and help control gene activity.	It might mimic exercise in female cortical tissue possibly by reshaping epigenetic programs that regulate activity‑dependent neuronal genes normally induced by physical activity.
D-4476	D‑4476 is a small molecule that appears to trigger changes in muscle cells similar to those seen after a workout.	It may mimic exercise by partially activating the AMPK signaling pathway, leading to increased mitochondrial biogenesis and fatty‑acid oxidation in vastus‑lateralis fibers.
epirubicin	Epirubicin is a chemotherapy drug that interferes with DNA replication, used to treat certain cancers.	It might push hippocampal cells away from an exercise-like state possibly by inducing DNA damage‑related stress pathways that suppress activity‑dependent gene expression.
bruceantin	Bruceantin is a natural plant‑derived compound studied for its anti‑cancer properties, and recent screening suggests it may shift kidney female cells away from a gene‑expression pattern associated with exercise‑like metabolic activity.	It might push cells away from an exercise‑like state possibly by inhibiting mitochondrial oxidative phosphorylation and altering energy‑sensing signaling pathways.
2-(dimethylamino)-1-[(8R,9S,10S)-10-(hydroxymethyl)-9-[4-[(E)-2-phenylethenyl]phenyl]-1,6-diazabicyclo[6.2.0]decan-6-yl]ethanone	The chemical is a lab‑made molecule that contains a dimethylamino group attached to a complex bicyclic framework, often studied for its biological effects.	It may drive spleen cells away from an exercise‑like state possibly by disrupting mitochondrial energy signaling or modulating inflammatory cytokine pathways.
tamoxifen	Tamoxifen is a medication that blocks estrogen receptors and is commonly used to treat certain breast cancers; it can also affect other tissues, including the heart.	It may push heart cells away from an exercise‑like state possibly by inhibiting estrogen‑mediated signaling pathways that support mitochondrial biogenesis and oxidative metabolism.
HG-5-113-01	HG-5-113-01 is a compound that appears to diminish the exercise‑related activity patterns of cells in the female hippocampus.	It might push cells away from an exercise‑like state by disrupting neurotrophic signaling pathways such as BDNF, thereby reducing activity‑enhancing effects.
olaparib	Olaparib is a medication that blocks a DNA‑repair enzyme called PARP and is used to treat some cancers.	It may mimic exercise by possibly activating stress‑responsive signaling that promotes mitochondrial activity and metabolic remodeling in adrenal tissue.
IKK-16	IKK-16 is a small‑molecule inhibitor that blocks the IκB kinase (IKK) pathway, a central regulator of inflammation and stress responses in brain cells.	Possibly, by dampening NF‑κB–mediated inflammatory signaling, IKK‑16 could promote neuronal plasticity and metabolic changes that resemble those induced by exercise.
KDM5A	KDM5A is an enzyme that modifies how genes are expressed in brown‑fat cells, influencing their activity.	Possibly by enhancing mitochondrial biogenesis and fatty‑acid oxidation pathways, it may mimic exercise‑induced energy‑burning in brown adipose tissue.
STBD1	STBD1 is a protein that helps move and store sugar molecules inside cells, influencing how fat tissue behaves.	It might mimic exercise in white adipose tissue possibly by enhancing glycogen turnover and activating signaling pathways that promote lipid mobilization.
2-(dimethylamino)-1-[(8R,9S,10R)-10-(hydroxymethyl)-9-[4-[(E)-2-phenylethenyl]phenyl]-1,6-diazabicyclo[6.2.0]decan-6-yl]ethanone	A synthetic small molecule featuring a bicyclic core, a dimethylamino group, and a phenyl‑vinyl side chain, being investigated for its effects on female liver tissue.	It may mimic exercise in the liver possibly by activating AMPK‑related pathways that boost mitochondrial fatty‑acid oxidation.
CD226	CD226 is a cell‑surface protein that helps immune cells attach to each other and send signals.	Possibly, CD226 activity may alter neuroimmune signaling in the hippocampus, reducing inflammation and promoting neurogenesis in a way that resembles exercise‑induced benefits.
mitoxantrone	Mitoxantrone is a chemotherapy drug that interferes with DNA replication and cell division.	It might push small‑intestine cells away from an exercise‑like state by disrupting DNA synthesis and activating stress pathways that suppress exercise‑associated gene expression.
levamisole	Levamisole is a drug originally used as an anti‑parasitic and immune‑modulating medication, sometimes repurposed in research for its effects on cellular signaling.	It might push heart cells away from an exercise‑like state possibly by disrupting nicotinic acetylcholine receptor signaling, which can alter calcium handling and metabolic pathways linked to exercise adaptation.
WZ-7043	WZ‑7043 is an experimental compound that appears to trigger changes in male testicular tissue resembling those that occur after regular physical exercise.	It may mimic exercise effects possibly by activating AMPK‑related signaling pathways that regulate cellular energy balance in testicular cells.
dolastatin-10	Dolastatin‑10 is a natural compound derived from marine organisms that blocks cell growth and has been investigated as a potential anticancer drug.	It might mimic exercise effects in male hypothalamus possibly by altering microtubule dynamics, which could modify neuronal signaling pathways linked to activity‑dependent metabolic regulation.
MIF	MIF is a protein that helps regulate inflammation and immune responses throughout the body.	It may mimic exercise effects in female blood by possibly modulating inflammatory pathways that are also activated during physical activity.
1-[(3R,9R,10S)-9-[[cyclohexylmethyl(methyl)amino]methyl]-12-[(2S)-1-hydroxypropan-2-yl]-3,10-dimethyl-13-oxo-2,8-dioxa-12-azabicyclo[12.4.0]octadeca-1(14),15,17-trien-16-yl]-3-naphthalen-1-ylurea	A synthetic small molecule that links a cyclohexyl‑containing side chain to a naphthyl‑urea core, designed to interact with cellular proteins.	It may mimic exercise effects in male heart tissue possibly by activating AMPK‑related pathways that promote mitochondrial biogenesis and improve cardiac energy metabolism.
rifabutin	Rifabutin is an antibiotic commonly used to treat infections such as Mycobacterium avium complex, especially in individuals with compromised immune systems.	It might push cells away from an exercise-like state possibly by triggering inflammatory signaling that interferes with the metabolic pathways normally activated by physical activity.
GPX3	GPX3 is an enzyme that helps protect cells from oxidative damage, and altering its activity could change how heart‑related tissues respond to exercise.	It might push cells away from an exercise-like state possibly by reducing antioxidant signaling that normally supports metabolic adaptations to exercise.
obatoclax	Obatoclax is an experimental drug that blocks proteins that keep cells alive, and it is being studied for its impact on colon cells.	It might push cells away from an exercise‑like state possibly by interfering with mitochondrial BCL‑2 family signaling that regulates metabolic and stress‑response pathways.
BRCA2	BRCA2 is a gene that helps repair DNA, and changes to its activity may disrupt normal brain cell function in female cortical tissue, making them less responsive to the benefits of exercise.	It might push cells away from an exercise‑like state possibly by impairing DNA repair pathways that are needed for activity‑induced neuronal plasticity.
3-[(4-Chloroanilino)methylidene]-2-(2-hydroxyethylimino)-9-methyl-4-pyrido[1,2-a]pyrimidinone	This is a synthetic chemical that joins a chlorine‑substituted aniline fragment to a fused pyridopyrimidine core.	It might possibly shift testicular cells away from an exercise‑like phenotype by inhibiting AMPK‑related energy‑sensing pathways.
verrucarin-a	Verrucarin‑a is a fungal toxin that can influence cellular signaling pathways and has been studied for its effects on muscle cells.	It may mimic exercise‑like responses in male gastrocnemius tissue possibly by activating AMPK signaling and enhancing mitochondrial biogenesis.
clozapine	Clozapine is an antipsychotic medication that, surprisingly, appears to trigger some of the same brain changes that regular physical activity does.	It may possibly mimic exercise by activating hypothalamic pathways that regulate energy balance and neuroplasticity, such as increasing dopamine and BDNF signaling.
saracatinib	Saracatinib is a drug that blocks Src family kinases, enzymes that help regulate cell signaling and growth.	It may push hypothalamic cells away from an exercise-like state possibly by inhibiting Src‑mediated pathways that normally promote metabolic and neuronal activity associated with physical activity.
OGT	OGT (O‑GlcNAc transferase) is an enzyme that adds small sugar tags to many proteins in brain cells, influencing how those cells respond to signals and can shift their molecular state.	It might push cells away from an exercise‑like state by possibly adding O‑GlcNAc modifications that suppress activity‑dependent gene‑expression pathways.
3-[(3aS,10bS)-2-[4-(3-hydroxypropoxy)phenyl]-4-oxo-5-prop-2-enyl-6,10b-dihydrooxazolo[4,5-d][2]benzazepin-3a-yl]propanoic acid tert-butyl ester	This is a synthetic organic compound with a complex ring structure that researchers have identified as a potential drug‑like molecule that could trigger some of the same cellular responses seen during physical exercise in male lung tissue.	It may mimic exercise by activating signaling pathways such as AMPK or PGC‑1α, leading to increased mitochondrial biogenesis and anti‑inflammatory effects in lung cells.
CTNNB1	CTNNB1 is a gene that encodes the protein beta‑catenin, a key player in how cells communicate and regulate growth.	It might push lung cells away from an exercise‑like state possibly by boosting beta‑catenin signaling that favors tissue remodeling over the metabolic programs normally induced by exercise.
KW-2478	KW‑2478 is an experimental compound that inhibits the stress‑response protein Hsp90, helping cells cope with damage.	It might mimic exercise in male cortical tissue possibly by modulating stress‑response signaling that enhances mitochondrial activity and synaptic plasticity.
SERPINA6	SERPINA6 is a blood protein that carries and regulates the hormone cortisol, which helps control stress and metabolism.	It may push cortical cells away from an exercise-like state possibly by limiting cortisol signaling, thereby decreasing activation of pathways that normally respond to physical activity.
gemcitabine	Gemcitabine is a chemotherapy drug that blocks DNA replication in rapidly dividing cells.	It might push cells away from an exercise‑like state possibly by inhibiting DNA synthesis and dampening the activation of metabolic pathways normally up‑regulated during muscle activity.
AFG3L2	AFG3L2 is a protein that helps maintain the health of mitochondria, the cell’s power plants, especially in the lining of the colon.	Possibly by disrupting mitochondrial energy production, it could dampen the metabolic signals that normally promote an exercise‑like state.
GW-843682X	GW-843682X is a small‑molecule compound that seems to diminish the exercise‑like metabolic profile of female liver cells.	It might push cells away from an exercise‑like state possibly by inhibiting AMPK signaling and altering key metabolic gene expression.
KU-0060648	KU‑0060648 is a small‑molecule drug that blocks a particular enzyme and is being explored for its effects on lung cells.	It might mimic aspects of exercise in male lung tissue possibly by activating AMPK signaling that enhances mitochondrial function.
MLN-2480	MLN‑2480 is an experimental compound that seems to cause ovarian cells to act less like they do after exercise.	It may push cells away from an exercise-like state by inhibiting a signaling pathway—such as AMPK or PGC‑1α—that normally mediates the cellular response to physical activity.
NSC-3852	NSC‑3852 is an experimental compound that appears to trigger some of the same cellular responses in female adrenal tissue that occur during physical exercise.	It may mimic exercise effects possibly by modestly activating AMPK signaling pathways that regulate energy balance and stress‑response genes.
SF3B1	SF3B1 is a protein that guides the editing of genetic messages inside cells, influencing how genes are expressed.	It may mimic exercise effects in male brown adipose tissue by altering RNA splicing of genes that control mitochondrial function and heat production.
licochalcone-a	Licochalcone‑a is a natural compound found in certain plants that has been shown to influence metabolism and gut function.	It may mimic exercise‑like effects in female small‑intestine tissue possibly by activating AMPK signaling pathways that enhance mitochondrial activity and nutrient uptake.
tacedinaline	Tacedinaline is a drug that blocks specific enzymes involved in gene regulation and has been found to affect brain cells in ways that may counteract the benefits of exercise.	It might push cells away from an exercise-like state possibly by inhibiting histone deacetylases, altering the expression of genes that normally respond to physical activity.
IKK-2-inhibitor-V	IKK-2-inhibitor-V is a drug that blocks the IKK‑2 protein, a key driver of inflammation.	It might mimic exercise in male small‑intestine tissue possibly by dampening NF‑κB signaling, thereby promoting metabolic and regenerative programs that are also stimulated by physical activity.
MLN-8054	MLN‑8054 is an experimental compound that inhibits Aurora A kinase, a protein that helps cells control division and growth.	It might mimic exercise in male spleen tissue possibly by triggering stress‑responsive signaling that enhances mitochondrial activity and immune cell remodeling.
C-646	C‑646 is a small‑molecule drug that inhibits a key enzyme (p300/CBP) that helps turn genes on by modifying DNA‑associated proteins.	It may push hypothalamic cells away from an exercise‑like state possibly by decreasing histone acetylation and thus lowering expression of genes that promote metabolic and activity responses.
AT-7519	AT‑7519 is an experimental drug that blocks cyclin‑dependent kinases, enzymes that help cells grow and divide, and is being investigated mainly for cancer therapy.	It could shift blood cells away from an exercise‑like state possibly by suppressing CDK‑driven transcription of metabolic and mitochondrial genes that are typically activated by physical activity.
thiotepa	Thiotepa is a chemotherapy drug that attaches to DNA and blocks cell division. Our screen suggests it may push male colon cells away from an exercise‑like state.	Possibly, thiotepa interferes with DNA repair pathways and alters the expression of metabolic genes that are normally up‑regulated by exercise, reducing the exercise‑like transcriptional program.
PI-103	PI‑103 is an experimental compound that blocks key signaling proteins (PI3K and mTOR) often targeted in cancer research.	It may push small‑intestine cells away from an exercise‑like state by inhibiting the PI3K/Akt pathway that normally drives metabolic and mitochondrial adaptations to physical activity.
vardenafil	Vardenafil is a drug commonly used to treat erectile dysfunction by relaxing blood vessels.	It might push kidney cells away from an exercise-like state by inhibiting PDE5, thereby altering cyclic GMP signaling and dampening metabolic pathways normally stimulated by exercise.
KCNMA1	KCNMA1 encodes a large potassium channel that helps muscle cells manage electrical signals and contract properly.	It might push cells away from an exercise‑like state possibly by dampening calcium‑dependent signaling pathways that normally drive metabolic remodeling during activity.
16beta-Bromoandrosterone	16β‑Bromoandrosterone is a synthetic steroid related to the natural hormone DHEA that can affect metabolism and hormone signaling.	It might mimic exercise in female heart tissue possibly by activating androgen receptors to promote mitochondrial biogenesis and improve calcium handling, similar to training‑induced cardiac adaptations.
SIN3A	SIN3A is a gene‑regulating protein that helps turn other genes on or off in many cell types.	It may push cells away from an exercise‑like state possibly by lowering the activity of genes that drive metabolic and vascular adaptations to physical activity.
MNITMT	MNITMT is a newly identified compound that appears to trigger changes in male vena‑cava tissue similar to those seen after physical exercise.	It may mimic exercise by possibly activating endothelial nitric‑oxide synthase and related metabolic signaling pathways.
N-[4-[[[6-(3,5-dimethyl-4-isoxazolyl)-4-quinazolinyl]amino]methyl]phenyl]acetamide	N-[4-[[[6-(3,5-dimethyl-4-isoxazolyl)-4-quinazolinyl]amino]methyl]phenyl]acetamide is a synthetic small‑molecule drug candidate that contains a quinazoline core linked to an isoxazole ring. It is being investigated for its ability to influence muscle cell behavior.	It might push gastrocnemius cells away from an exercise-like state by inhibiting pathways such as AMPK signaling or by interfering with transcription factors that promote oxidative metabolism.
trimethobenzamide	Trimethobenzamide is a drug commonly used to prevent nausea and vomiting by blocking signals in the brain.	It might mimic some exercise effects possibly by stimulating peripheral catecholamine release that enhances vascular tone and metabolic activity.
YM-155	YM-155 is an experimental drug that blocks the cancer‑related protein survivin and is being investigated for its effects on cell behavior.	It may push cells away from an exercise‑like state possibly by diminishing survivin‑driven mitochondrial activity and stress‑response pathways.
norgestrel	Norgestrel is a synthetic hormone similar to progesterone that is often used in birth‑control pills.	It might mimic some exercise‑related effects in ovarian tissue possibly by modulating steroid‑responsive pathways that influence mitochondrial activity and local inflammation.
ethoprop	Ethoprop is a synthetic pesticide that can enter the brain and alter cellular signaling pathways.	Possibly it disrupts estrogen‑dependent signaling in hypothalamic neurons, reducing the gene programs that support an exercise‑like metabolic state.
CSK	CSK is a protein that normally restrains certain signaling enzymes, and tweaking its activity in brown‑fat cells can make those cells act more like they do during exercise.	Possibly by relieving inhibition of Src family kinases, which could boost mitochondrial activity and thermogenic gene expression in female brown‑adipose tissue.
vismodegib	Vismodegib is a medication that blocks the Hedgehog signaling pathway, a key regulator of cell growth, and is used to treat some cancers.	It may push lung cells away from an exercise‑like state by dampening Hedgehog‑driven metabolic and proliferative programs that are normally enhanced during physical activity.
diminazene-aceturate	Diminazene‑aceturate is a drug historically used to treat parasitic infections in livestock and in some experimental studies.	It may mimic exercise in female vastus lateralis by possibly triggering cellular stress pathways that enhance mitochondrial function and muscle remodeling.
SB-939	SB‑939 is an experimental small‑molecule drug that induces gene‑expression changes in female blood cells resembling those observed after physical exercise.	It might mimic exercise possibly by modulating the PGC‑1α/NRF1 signaling pathway that drives mitochondrial biogenesis and oxidative metabolism.
4-(4-hydroxy-2,6-dimethylheptan-4-yl)-N,N-diphenyl-1-triazolecarboxamide	A synthetic molecule that links a triazole ring to two phenyl groups and a branched hydrocarbon side chain, being investigated for its potential to act like exercise in the brain.	It may mimic exercise in male cortical tissue by possibly activating AMPK signaling, leading to modest increases in mitochondrial biogenesis and neurotrophic factor expression.
BMS-387032	BMS‑387032 is an experimental drug that blocks specific cyclin‑dependent kinases, proteins that help cells divide and respond to signals.	It may push small‑intestine cells away from an exercise‑like state by dampening CDK‑mediated transcription of metabolic and mitochondrial genes needed for that phenotype.
(3S,3'S,4'R,5'S)-5'-(2-hydroxyethyl)-5-iodo-4'-[(4-methoxyphenyl)-dimethylsilyl]-3'-methyl-1-prop-2-enyl-2-spiro[indole-3,2'-oxolane]one	A complex synthetic molecule with iodine, a silicon‑containing group, and multiple chiral centers, resembling a small natural‑product fragment.	It may push heart cells away from an exercise‑like state by possibly disrupting signaling pathways that control mitochondrial biogenesis and oxidative metabolism.
SLC2A4RG	SLC2A4RG is a gene that influences how brain cells handle glucose, and tweaking its activity could create changes in the cortex that resemble those caused by exercise.	It may mimic exercise effects possibly by adjusting neuronal glucose uptake and activating signaling pathways that support neuroplasticity.
alsterpaullone	Alsterpaullone is a research drug that blocks enzymes involved in cell division, often used to study how cells grow.	It may push spleen cells away from an exercise‑like state possibly by inhibiting CDK and GSK‑3β signaling, disrupting pathways that normally activate the exercise‑associated transcriptional program.
panobinostat	Panobinostat is a medication that blocks enzymes called histone deacetylases, loosening DNA packaging and changing how genes are turned on or off, and is used primarily to treat certain cancers.	It might push spleen cells away from an exercise-like state possibly by altering histone acetylation patterns that suppress exercise‑responsive gene programs.
salmeterol	Salmeterol is a long‑acting asthma medication that relaxes airway muscles and helps keep breathing easy.	It may mimic exercise in male liver possibly by activating β2‑adrenergic receptors, raising cAMP levels and promoting metabolic pathways such as fatty‑acid oxidation and mitochondrial biogenesis.
5H-quinolino[8,7-c][1,2]benzothiazine 6,6-dioxide	5H-quinolino[8,7-c][1,2]benzothiazine 6,6-dioxide is a synthetic heterocyclic molecule that researchers are studying for its effects on brain cells.	It may mimic aspects of exercise possibly by activating AMPK pathways and increasing neurotrophic factor expression in female cortical tissue.
CC-930	CC‑930 is an experimental drug that inhibits the p38 MAP‑kinase enzyme, a key player in cellular stress and inflammatory signaling.	It may push liver cells away from an exercise‑like state possibly by suppressing p38‑MAPK–driven metabolic pathways that are normally activated during exercise.
nilotinib	Nilotinib is a drug that blocks specific enzymes involved in cell growth and is being studied for its effects on brain cells.	It may push hypothalamic female cells away from an exercise‑like state possibly by inhibiting signaling pathways that normally stimulate metabolic and neuropeptide genes.
ST-4062971	ST-4062971 is an experimental compound that appears to trigger cellular changes similar to those seen after physical exercise, particularly in male kidney tissue.	It may mimic exercise effects by partially activating metabolic and stress‑response pathways such as AMPK or PGC‑1α signaling.
VX-745	VX-745 is a small‑molecule inhibitor of an inflammatory kinase that, in early studies, appears to induce lung‑cell changes reminiscent of those produced by physical exercise.	It may mimic exercise possibly by activating the AMPK pathway, thereby boosting mitochondrial activity and anti‑inflammatory signaling in female lung tissue.
ARFGEF2	ARFGEF2 is a gene that helps cells move and communicate, and changing its activity may cause hypothalamic cells in females to behave less like they do during exercise.	Possibly by disrupting vesicle trafficking and thereby weakening signaling pathways that promote exercise‑like metabolic activity.
THZ-2-98-01	THZ-2-98-01 is a small‑molecule compound that appears to induce exercise‑like changes in female gastrocnemius muscle tissue.	It may mimic exercise possibly by activating AMPK signaling pathways that promote mitochondrial biogenesis and metabolic remodeling.
HAL	HAL is a compound that appears to coax cells in the male vena‑cava to adopt changes typically seen after physical activity.	Possibly, it mimics exercise by modestly activating nitric‑oxide signaling and related metabolic pathways that promote vascular remodeling.
KIN001-043	KIN001-043 is a small‑molecule inhibitor that targets a signaling kinase and is being studied for its effects on kidney cells.	It could mimic exercise in male kidney tissue possibly by activating AMPK‑driven metabolic pathways that enhance mitochondrial function and promote a more oxidative phenotype.
bosutinib	Bosutinib is a cancer drug that blocks specific enzymes called tyrosine kinases, which are involved in cell growth.	It might mimic exercise in adrenal male tissue possibly by inhibiting Src‑family kinases that influence catecholamine production and stress‑response signaling.
PIM1	PIM1 is a protein‑kinase that helps cells grow, survive, and regulate metabolism, and it has been identified as a candidate that could reproduce some exercise‑like effects in female brown‑fat tissue.	It may mimic exercise by activating signaling pathways that boost mitochondrial activity and promote fatty‑acid oxidation in brown adipocytes.
UK-356618	UK-356618 is a small‑molecule compound that appears to diminish the exercise‑like molecular signature of cells in male vena‑cava tissue.	It may push cells away from that state possibly by inhibiting a metabolic signaling pathway such as AMPK or PPAR that normally drives the exercise‑associated program.
nocodazole	Nocodazole is a laboratory drug that interferes with microtubule formation, the cellular scaffolding that helps cells divide and move.	It might mimic exercise effects in female spleen tissue possibly by altering microtubule dynamics, thereby reshaping immune cell trafficking and signaling in a way similar to the physiological stress of physical activity.
romidepsin	Romidepsin is a cancer medication that blocks enzymes called histone deacetylases, thereby influencing how genes are turned on or off.	It might mimic exercise in vena‑cava tissue possibly by modifying histone deacetylase activity, which could shift gene expression toward pathways that regulate muscle contraction, energy use, and vascular remodeling.
alisertib	Alisertib is a drug that blocks a protein called Aurora A, which helps cells divide and is being explored as a cancer therapy.	It might mimic some exercise‑related changes in female colon tissue possibly by dampening stress‑responsive pathways and shifting metabolic signaling in a way similar to physical activity.
fulvestrant	Fulvestrant is a medication that blocks estrogen receptors and is used to treat some breast cancers.	It might push adrenal cells away from an exercise-like state possibly by antagonizing estrogen signaling that supports metabolic pathways linked to exercise.
2-Amino-4-(4-chlorophenyl)-1-(4-methylphenyl)-6-oxopyridine-3,5-dicarbonitrile	2‑Amino‑4‑(4‑chlorophenyl)‑1‑(4‑methylphenyl)‑6‑oxopyridine‑3,5‑dicarbonitrile is a small organic compound featuring a pyridine core with aromatic and nitrile substituents.	It might mimic exercise in female spleen tissue possibly by influencing metabolic regulators such as AMPK or PPARγ, thereby altering immune‑cell activity.
(3S)-2-[(S)-tert-butylsulfinyl]-3-(2-hydroxyethyl)-4-[3-(3-methoxyphenyl)phenyl]-N-(2,2,2-trifluoroethyl)-1,3-dihydropyrrolo[3,4-c]pyridine-6-carboxamide	This synthetic compound, featuring a sulfoxide group attached to bulky aromatic structures, is being studied for its ability to influence male testicular tissue.	It may mimic exercise by possibly activating AMPK pathways and attenuating oxidative stress within the testes.
LY-2835219	LY-2835219, also known as abemaciclib, is a medication that blocks proteins called CDK4 and CDK6 to slow the growth of certain cancers.	It may mimic exercise effects by altering cell‑cycle signaling and metabolic pathways that are also activated during physical activity.
N-(2-methoxyphenyl)-N-[(3-oxo-1-benzothiophen-2-ylidene)amino]acetamide	N-(2‑methoxyphenyl)-N‑[(3‑oxo‑1‑benzothiophen‑2‑ylidene)amino]acetamide is a small organic molecule used in laboratory research.	It might mimic exercise in female kidney tissue by possibly activating AMPK‑related pathways that regulate cellular energy metabolism.
ACAN	ACAN is a gene that makes a key structural protein in the extracellular matrix, and adjusting its activity in brown‑fat cells seems to boost the tissue’s metabolic tone in a way that resembles the effects of exercise.	It possibly mimics exercise by altering matrix composition, which could enhance brown‑fat signaling pathways that drive thermogenesis and energy expenditure.
calcitriol	Calcitriol is the active form of vitamin D that helps regulate calcium balance and influences various cellular processes throughout the body.	It might push testicular cells away from an exercise‑like state possibly by altering calcium‑dependent signaling pathways that modulate metabolic and androgen‑responsive gene programs.
NDUFS6	NDUFS6 encodes a component of mitochondrial complex I, a key enzyme that helps cells generate energy.	It may push heart cells away from an exercise-like state possibly by weakening complex I activity, lowering ATP production, and dampening the metabolic remodeling normally triggered by exercise.
BX-795	BX‑795 is a research drug that blocks the activity of specific signaling enzymes called kinases, which cells use to communicate.	It may push brown‑adipose cells away from an exercise‑like state possibly by inhibiting TBK1/IKKε, dampening the metabolic pathways that normally mimic exercise.
PPP2CA	PPP2CA encodes a component of the protein phosphatase 2A enzyme, which helps regulate numerous cellular functions.	Disrupting PPP2CA may push kidney cells away from an exercise‑like state possibly by altering phosphorylation signaling that controls metabolism and stress‑response pathways.
rasagiline	Rasagiline is a medication that inhibits the enzyme MAO‑B, raising dopamine levels and is commonly prescribed for Parkinson’s disease.	It may shift small‑intestine male cells away from an exercise‑like state possibly by dampening mitochondrial respiration and lowering the reactive‑oxygen‑species signals that drive that phenotype.
RAPGEF6	RAPGEF6 is a cellular signaling protein that helps turn on other proteins, influencing how cells respond to stimuli, especially in muscle and nerve tissue.	It may possibly mimic exercise by activating Rac1‑mediated pathways that enhance mitochondrial biogenesis and glucose uptake in muscle.
HADH	HADH is an enzyme that helps brown‑fat cells break down fatty acids to produce heat and energy.	It might push cells away from an exercise‑like state by possibly reducing fatty‑acid oxidation and lowering thermogenic signaling.
berbamine	Berbamine is a natural alkaloid derived from the plant *Berberis* that has been studied for its anti‑inflammatory and anti‑cancer properties.	It might mimic exercise in gastrocnemius tissue possibly by modulating calcium signaling and activating AMPK pathways that promote metabolic and mitochondrial adaptations.
pyocyanin	Pyocyanin is a blue‑green toxin secreted by the bacterium *Pseudomonas aeruginosa* that can influence cellular signaling and immune responses.	It might mimic exercise by possibly triggering oxidative‑stress and redox‑responsive pathways that produce metabolic and inflammatory changes similar to those seen during physical activity.
MAP2K3	MAP2K3 is a protein that helps cells respond to signals that control growth and stress.	It might mimic exercise effects by potentially activating downstream pathways that promote muscle remodeling and metabolic adaptation.
medroxyprogesterone	Medroxyprogesterone is a synthetic hormone similar to natural progesterone, commonly used in birth‑control pills and hormone therapy, and it helps regulate the menstrual cycle and metabolism.	It might mimic exercise effects in female small‑intestine tissue possibly by activating progesterone receptors that alter mitochondrial function and nutrient‑transport pathways.
lidocaine	Lidocaine is a local anesthetic often used to numb tissue during medical procedures, working by blocking nerve signals.	It might push adrenal cells away from an exercise‑like state possibly by inhibiting voltage‑gated sodium channels that are needed for catecholamine release during stress.
N-[(4-methylphenyl)methyl]-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine	N-[(4-methylphenyl)methyl]-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine is a synthetic small‑molecule compound that can enter adrenal cells.	It may push adrenal cells away from an exercise‑like state possibly by interfering with catecholamine signaling or stress‑responsive gene regulation.
atorvastatin	Atorvastatin is a widely used medication that lowers cholesterol and helps prevent heart disease.	It may mimic exercise‑like changes in the male hippocampus possibly by modulating neuroinflammatory pathways and improving cerebral blood flow.
rigosertib	Rigosertib is an experimental drug originally developed to block cancer cell growth, but recent lab tests suggest it can trigger some of the same changes in muscle that happen after a workout.	It may mimic exercise by possibly interfering with signaling pathways such as the Ras‑Raf‑MEK‑ERK cascade, leading to altered metabolism and stress‑response genes in muscle fibers.
CCND3	CCND3 encodes a cyclin that drives cells through the division cycle, helping tissues grow and renew, and its activity influences how vascular cells in the vena cava proliferate.	Possibly, elevated CCND3 pushes cells away from an exercise-like state by favoring cell‑cycle progression over the metabolic and structural adaptations normally induced by exercise.
HTR1F	HTR1F encodes a serotonin receptor that influences mood and metabolic regulation in the brain.	It might push hypothalamic cells away from an exercise‑like state possibly by dampening serotonin signaling that normally activates energy‑burning pathways.
PMF1-BGLAP	PMF1‑BGLAP is a genetic perturbation that appears to diminish the exercise‑like benefits normally seen in male white‑adipose tissue.	It might push cells away from an exercise‑like state possibly by interfering with signaling pathways that regulate mitochondrial function and lipid metabolism.
IL18BP	IL18BP is a protein that binds and neutralizes the inflammatory signal interleukin‑18, helping to keep inflammation in check.	It might mimic exercise effects in female white‑adipose tissue possibly by reducing IL‑18–driven inflammation and thereby enhancing metabolic pathways linked to fat burning.
wortmannin	Wortmannin is a natural compound that blocks a key cell‑signaling pathway and is frequently used in laboratory research.	It might mimic exercise in female hypothalamus possibly by dampening PI3K/Akt signaling, thereby altering neuronal energy‑sensing and hormone‑regulating processes.
2-Amino-1-(4-methylphenyl)-6-oxo-4-phenylpyridine-3,5-dicarbonitrile	2‑Amino‑1‑(4‑methylphenyl)‑6‑oxo‑4‑phenylpyridine‑3,5‑dicarbonitrile is a synthetic organic molecule featuring a pyridine core attached to aromatic and nitrile groups.	It might mimic aspects of exercise in male white‑adipose tissue by possibly activating AMPK signaling and modestly influencing PPARγ‑driven browning pathways.
SLC2A5	SLC2A5 encodes a sugar‑transport protein that helps brain cells bring in fructose for energy, and our screen suggests boosting it may produce some of the same brain benefits seen after exercise in male hippocampus.	It might mimic exercise effects possibly by enhancing neuronal carbohydrate uptake and supporting metabolic pathways linked to plasticity and memory.
PRKRA	PRKRA is a cellular protein that helps regulate how genes respond to stress and signaling cues.	It may mimic exercise by possibly activating stress‑responsive pathways that boost metabolic gene expression in blood cells.
mercaptopurine	Mercaptopurine is a drug commonly prescribed for leukemia and autoimmune conditions that works by disrupting the creation of new DNA in rapidly dividing cells.	Possibly, it mimics aspects of exercise in male lung tissue by modestly triggering cellular stress responses that enhance mitochondrial function and reduce inflammation.
clomifene	Clomifene is a medication that helps stimulate ovulation in women and is sometimes used in fertility treatments.	Possibly by modulating estrogen‑responsive pathways that influence lipid metabolism and mitochondrial function.
RRM1	RRM1 is a gene that produces a key enzyme for making the building blocks of DNA, helping cells grow and divide.	It may push cortical cells away from an exercise‑like state possibly by limiting nucleotide pools needed for activity‑dependent transcriptional programs.
diltiazem	Diltiazem is a calcium‑channel blocker often prescribed for high blood pressure and heart rhythm disorders, helping to relax blood vessels and lower cardiac workload.	It might push colon cells away from an exercise-like state possibly by dampening calcium‑dependent signaling that drives metabolic and contractile adaptations.
sorafenib	Sorafenib is an oral cancer medication that blocks multiple proteins involved in cell growth and blood‑vessel formation.	It might mimic exercise effects in female gastrocnemius muscle by possibly inhibiting MAPK/ERK signaling, leading to altered muscle metabolism and vascular remodeling.
TFRC	TFRC is a gene that helps cells import iron, and changing its activity in male brown‑fat tissue appears to make the cells behave less like they do after exercise.	This effect may be due to reduced TFRC limiting iron‑dependent enzymes that support mitochondrial function, thereby dampening the metabolic boost typically induced by exercise.
doxorubicin	Doxorubicin is a chemotherapy medication commonly used to treat various cancers.	It might push cells away from an exercise-like state possibly by inducing DNA damage and oxidative stress that suppresses metabolic and signaling pathways associated with physical activity.
clomethiazole	Clomethiazole is a sedative medication that reduces brain activity and is occasionally used to manage alcohol withdrawal symptoms.	It might push lung cells away from an exercise‑like state possibly by dampening metabolic signaling through activation of GABA‑A receptors.
dexamethasone	Dexamethasone is a synthetic steroid medication commonly used to reduce inflammation and suppress immune responses.	It may push testicular cells away from an exercise-like state possibly by activating glucocorticoid receptors that dampen metabolic pathways associated with physical activity.
tivozanib	Tivozanib is a cancer drug that blocks blood‑vessel growth signals, and researchers have found it may produce changes in the female brain that look like those seen after physical exercise.	It might mimic exercise effects by possibly enhancing neurovascular remodeling and metabolic signaling pathways similar to those activated during aerobic activity.
N-(3,4-dimethylphenyl)-2-oxo-3,4-dihydro-1H-quinoline-6-sulfonamide	N-(3,4-dimethylphenyl)-2-oxo-3,4-dihydro-1H-quinoline-6-sulfonamide is a synthetic small‑molecule that combines a quinoline ring with a sulfonamide group.	It may push white‑adipose cells away from an exercise‑like state possibly by inhibiting signaling pathways (e.g., AMPK or PPARγ) that normally enhance mitochondrial activity and fatty‑acid oxidation.
genistein	Genistein is a natural compound found in soybeans that can act like a mild hormone and has been studied for its health effects.	It might mimic exercise in ovarian tissue by possibly activating estrogen‑related pathways that enhance mitochondrial function and improve blood flow.
mitomycin-c	Mitomycin‑C is a chemotherapy drug that damages DNA and is used to treat certain cancers.	It may push liver cells away from an exercise‑like state possibly by causing DNA cross‑links that trigger stress pathways and suppress metabolic programs normally induced by exercise.
GPR22	GPR22 is a receptor on kidney cells that seems to oppose the healthy changes typically triggered by exercise.	It could push cells away from an exercise-like state possibly by disrupting cAMP‑mediated signaling pathways that drive metabolic remodeling.
cucurbitacin-i	Cucurbitacin‑i is a bitter plant‑derived compound found in cucumbers and other members of the gourd family, known for its anti‑inflammatory and metabolic effects. It has been investigated for its ability to modulate cellular signaling pathways related to energy balance.	Possibly, it mimics exercise by activating AMPK signaling and enhancing mitochondrial biogenesis in hypothalamic neurons, leading to metabolic adaptations similar to those triggered by physical activity.
N-(2-aminophenyl)-N'-[(2R,3R)-2-[[(4-chlorophenyl)sulfonyl-methylamino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]heptanediamide	A lab‑made chemical that can bind to proteins and influence how cells behave.	It may push heart cells away from an exercise‑like state by possibly disrupting mitochondrial energy production or interfering with signaling pathways that normally drive exercise‑induced adaptations.
PLEKHM1	PLEKHM1 is a gene that encodes a protein helping cells transport and recycle internal material, a process important for cell health.	It may push liver cells away from an exercise‑like state possibly by impairing autophagy and lysosomal trafficking that normally support metabolic adaptations to exercise.
ponatinib	Ponatinib is a cancer drug that blocks a protein called BCR‑ABL, helping to stop the growth of certain tumors.	It might mimic exercise in male liver by possibly activating AMPK signaling, which promotes metabolic pathways similar to those induced by physical activity.
salermide	Salermide is a small‑molecule drug that blocks the activity of sirtuin proteins, which help regulate metabolism and stress responses.	It may push cells away from an exercise‑like state possibly by inhibiting SIRT1/2‑driven mitochondrial biogenesis and fatty‑acid oxidation that are normally stimulated by exercise.
JNJ-7706621	JNJ-7706621 is an experimental compound that seems to dampen the exercise-like activity of muscle cells in the male gastrocnemius.	It may push cells away from an exercise-like state possibly by inhibiting a kinase that normally promotes metabolic and contractile programs associated with physical activity.