Original MoTrPAC-Man presentation logo: a running yellow rat collecting molecular pelletsLIVER LEVEL
HEPATIC HIDEOUTREADY TO EXPLORE
SCORE 0BEST 0CAT PICKUPS 0Pickups readyLiver tissue · baseline
LEVEL 01 / INTRODUCTION

Choose your runner.
Explore exercise biology.

Four runners. Same rules. Female and male choices select the corresponding data. Human runners are avatars; current rankings still use rat exercise signatures.

Read the cats. Marked tiles warn of attacks. Purple tiles are shortcuts. Collect wind-up cheese; press Q to distract one cat. Lung adds wall jumps. Heart ends with a final chase.

HOW TO PLAY1. Move. Arrow keys or WASD. On mobile, swipe or use the direction pad.2. Collect. Collect perturbations to reach arcade stage +5. Wait 5 seconds between pickups.3. Open the exit. Tap ◎ or press Space nearby to discover the organ, reach +5, and collect the treadmill. Then enter ★ EXIT. Cat contact ends the run. Use a stored shoe with Space or Use shoe.
Swipe the map
or tap to steer
YOUR MISSIONDiscover ◎. Reach +5. Collect the treadmill. Enter ★.
INTRODUCTION · 2 cats
Shoe · find a pickup
HUMAN LIVER LABFrom organ to cell
Human liver, front viewThe larger right lobe appears on the viewer’s left and the smaller left lobe on the viewer’s right. The falciform ligament separates these anatomical lobes on the front surface. The gallbladder sits underneath. Caudate and quadrate lobes are on the back and underside, outside this view.Right lobeLeft lobeFalciform ligamentGallbladderFront view · patient’s right is on your left
01 / THE ORGAN

Your body’s processing hub.

The liver sits mainly under your right ribs. Its larger right lobe and smaller left lobe meet at the falciform ligament on the front surface.

The caudate and quadrate lobes lie on the back and underside. The gallbladder beneath the liver stores and concentrates bile.

Human anatomy guides the silhouette. Enlarged cell details show hepatocytes, nuclei, and sinusoidal spaces. Organ and cell scales are combined for learning; maze corridors are not blood vessels. Exercise data may come from rats, and LINCS profiles come from cell experiments.
02 / INSIDE A LOBULE
Human liver lobule: blood enters at the edge, bile drains outwardHepatocyte plates lie between sinusoids. Portal vein and hepatic artery branches supply blood that drains to the central vein. Separate bile canaliculi carry bile from hepatocytes toward bile ducts in portal tracts. Idealized cross-section, not to scale.CVCLASSIC LIVER LOBULEIdealized cross-section · boundary is conceptualCentralvein (CV)Portaltriad
Blood → central veinBile → portal bile ducts

Blood in. Bile out.

Blood enters from portal vein and hepatic artery branches, passes through sinusoids, and drains into a central vein.

Bile travels separately. Hepatocytes make it; tiny channels called canaliculi carry it toward bile ducts at the lobule’s edge.

Portal triad: a portal vein branch , a hepatic artery branch , and a bile duct .

Hepatocytes process nutrients, store glycogen, and metabolize many drugs.

Idealized human lobule, not to scale. Human lobule boundaries are less distinct than this teaching diagram suggests.
NIH human anatomy ↗Leeds histology ↗
HUMAN LUNG LABEvery breath counts
Human lungs, front viewRight lung on the viewer’s left has three lobes, separated by horizontal and oblique fissures. Left lung on the viewer’s right has two lobes and a cardiac notch. The trachea branches into main bronchi. The diaphragm lies below both lungs.UpperMiddleLowerUpperLowerRIGHTLEFTTracheaDiaphragmHeartspace
Front view · patient’s right is on your left

One airway becomes millions.

The trachea branches into bronchi, then smaller bronchioles. At their ends, tiny alveoli exchange oxygen and carbon dioxide with blood.

The right lung has three lobes; the left has two. The left lung’s cardiac notch leaves room for the heart.

The diaphragm contracts downward as you inhale and relaxes upward as you exhale.

The maze and moving particles are teaching illustrations, not a simulation of airflow or drug effects.
NIH lung anatomy ↗NIH breathing guide ↗
HUMAN HEART LABTwo pumps. One circuit.
Four chambers and the path of bloodSimplified flow diagram, not a scale drawing. Blood returning from the body enters the right atrium, passes the tricuspid valve into the right ventricle, then travels through the pulmonary valve and arteries to the lungs. It returns through pulmonary veins to the left atrium, passes the mitral valve into the left ventricle, and leaves through the aortic valve and aorta for the body.Right atriumRight ventricleLeft atriumLeft ventricleLungsBodyTricuspid valveMitral valve
Schematic flow guide · chambers are not to scale

Follow the blood.

Body → right atrium → right ventricle → lungs. Pulmonary arteries carry blood to the lungs to collect oxygen.

Lungs → left atrium → left ventricle → body. Pulmonary veins return oxygen-rich blood. The left ventricle pumps it into the aorta.

Four valves keep blood moving forward. The left ventricle has a thicker wall and forms the heart’s apex.

Coronary arteries supply the heart muscle itself.

The game uses a stylized human heart map. Its corridors are arcade paths, not blood vessels.
NIH heart anatomy ↗NIH blood flow ↗
MOLECULAR TRAIL · CLICK TO REVIEW
Your choices appear here.
CAT TRAIL · CLICK TO REVIEW
Cat pickups appear here.
MoTrPAC × LINCSScores reflect an exercise signature, not drug safety. Character animations are game effects.
Why treadmill running?

MoTrPAC’s 2024 endurance study used progressive treadmill training in male and female rats, with groups trained for 1, 2, 4, or 8 weeks. The protocol used five training days per week.

Our rat’s outfits, couch scenes, and running stages add arcade flair. The −5 to +5 score represents signature matching, not training weeks, measured fitness, or a drug’s effect on endurance.

Nature study ↗ · Training protocol ↗
Source data: Tissue rankings · Perturbation descriptions · GitHub